FRONTLINE Plus for Dogs Flea & Tick Large Breed Dog Spot Treatment, 45 - 88 lbs, 3 Count
FRONTLINE Plus for Dogs Flea & Tick Large Breed Dog Spot Treatment, 45 - 88 lbs, 3 Count
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FRONTLINE Plus for Dogs Flea & Tick Large Breed Dog Spot Treatment, 45 - 88 lbs, 3 Count

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FRONTLINE Plus for Dogs Flea & Tick Large Breed Dog Spot Treatment, 45 - 88 lbs, 3 CountFRONTLINE Plus For Dogs Flea Tick Large Breed Dog Spot Treatment 45 88 lbs 3ctFRONTLINE Plus For Dogs Flea Tick Large Breed Dog Spot Treatment 45 88 lbs 6ctFRONTLINE Plus For Dogs Flea Tick Large Breed Dog Spot Treatment 45 88 lbs
Count Per Pack3

Key item features

  • Provides fast-acting, long-lasting flea and tick protection
  • Trusted by Pet Owners for 20 years . References: 2. Data on file at Boehringer Ingelheim.
  • Kills adult fleas, flea eggs, flea larvae, and ticks
  • Rapidly eliminates chewing lice infestations
  • Aids in the control of sarcoptic mange infestations
  • Waterproof
  • Easy to apply once a month for lasting protection
  • For best results, apply every month
  • FRONTLINE

Specs

Brand, FRONTLINEAnimal type, DogWeight range, LargePet size, LargeMinimum weight, 1 lbMax Weight, 132 lb

About this item

Product details

Keep your dog protected with the #1 name in flea & tick protection*, FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle β€” FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years**β€” FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations and keep your pets protected year-round.

References: 
*Data on file at Boehringer Ingelheim.
**Data showing 20 years of trust in killing fleas and ticks is on file at Boehringer Ingelheim.

  • Provides fast-acting, long-lasting flea and tick protection
  • Trusted by Pet Owners for 20 years . References: 2. Data on file at Boehringer Ingelheim.
  • Kills adult fleas, flea eggs, flea larvae, and ticks
  • Rapidly eliminates chewing lice infestations
  • Aids in the control of sarcoptic mange infestations
  • Waterproof
  • Easy to apply once a month for lasting protection
  • For best results, apply every month
  • FRONTLINE
info:
We aim to show you accurate product information. Manufacturers, suppliers and others provide what you see here, and we have not verified it.Β Β 

Specifications

Brand

FRONTLINE

Animal type

Dog

Weight range

Large

Pet size

Large

Indications

Directions

Dosage

One dose every 30 days

Instructions

READ ENTIRE LABEL BEFORE EACH USE. To apply, simply follow these instructions and repeat every 30 days: Use scissors to separate one FRONTLINE Plus for Dogs blister and cut along dotted line to peel down foil to remove the applicator. Open the applicator by holding upright with foil side toward you and snap applicator tip. Next, part your dog's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry. Do not allow your dog to ingest this product. [Do not apply to dogs weighing less than [5 lbs.] [23 lbs.] [45 lbs.] [89 lbs.] or younger than 8 weeks of age.][Do not use two applicators for dogs weighing more than 132 lbs.] Do not use more than one application per dog per month.

Feeding Instructions

For use only on dogs 45 to 88lbs. Directions for Use. It is a violation of Federal Law to use this product in a manner inconsistent with its labeling. Do not allow children to apply product. To prevent harm to you and your pet, read entire label and enclosed directions before each use. Follow all directions and precautionary statements carefully. Use on dogs only. Do not use on rabbits. Do not use on other animals. Pets may experience some temporary irritation at the site of application. Please see insert for additional information. To kill fleas, flea eggs & larvae, ticks, and chewing lice apply Frontline Plus for dogs as follows:. To Remove Applicator: Lift and remove the plastic tab to expose foil backing; then peel away the foil. Or use scissor to open. Open Applicator. Hold upright with foil side toward you and snap applicator tip. Apply Frontline Plus. Part the dog's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the dog's skin. Do not apply on top of the hair coat. Avoid contact with treated area until dry. Do not allow your dog to ingest the product. Do not apply to dogs weighing less than 45 lbs. or younger than 8 weeks of age. Do not use more than one application per dog per month. Frontline Plus is approved for use on all dogs, including breeding, pregnant, and lactating bitches and puppies as young as 8 weeks. Frontline Plus remains effective even after bathing, water immersion, or exposure to sunlight. Side Effects: Pets may experience some temporary irritation at the site of application. If signs persist or become more severe within a few days of application, consult a veterinarian immediately. Frequency of Application. When used monthly, Frontline Plus completely breaks the flea life cycle and controls tick and chewing lice infestations. Do not reapply Frontline Plus for 30 days. Frontline Plus kills adult fleas, flea eggs, and flea larvae for up to three months. Frontline Plus also prevents development of all flea stages for up to three months. Frontline Plus can control fleas for up to three months, however, if there is a high risk of reinfestation or if the pet has fleas which may cause flea allergy dermatitis, a once monthly application may be needed. Frontline Plus kills ticks for at least one month. A once monthly application is recommended where tick control is needed. Frontline Plus kills all life stages of ticks (larva, nymph and adult). Frontline Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis and other tick-borne diseases. Frontline Plus kills chewing lice for at least one month. A once monthly application is recommended where chewing lice control is needed. Frontline Plus aids in the control of sarcoptic mange infestations. Multiple monthly treatments are recommended for the elimination of mites.

Warranty

Warranty information

All products come with a 90 Day, or longer, manufacturer warranty

Please be aware that the warranty terms on items offered for sale by third party Marketplace sellers may differ from those displayed in this section (if any). To confirm warranty terms on an item offered for sale by a third party Marketplace seller, please use the 'Contact seller' feature on the third party Marketplace seller's information page and request the item's warranty terms prior to purchase.

Ingredients

Warnings

Customer ratings & reviews

4.2 out of 5 stars
stars
14K ratings3,754 reviews
Includes global ratings and reviews
How item rating is calculated
  1. 5 stars68% (9,501)
  2. 4 stars11% (1,499)
  3. 3 stars6% (774)
  4. 2 stars4% (512)
  5. 1 star13% (1,756)
Filtered and sorted results would be available on the new 'Customer ratings & reviews' page.
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Showing 1-3 of 3,754 reviews

Nov 4, 2026
Reviewer name: Joanne
Top Reviewer
Item details
Count per pack: 3
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

Years of reliable, tick and flea protection

I've been using FRONTLINE Plus on my Vizsla for years. We spend a lot of time hiking in the woods, so flea and tick protection is especially important to me. She's remained free of fleas and ticks while using this product. I even asked my veterinarian if I should consider switching to one of the longer-lasting treatments, but he said that as long as FRONTLINE is working well, there's no reason to change. That's good enough for me! I'll continue using a product that has worked so well for us.

Helpful?8b81c8a0-bb12-11f1-becc-af82cebedb1824471380
Sep 25, 2026
Reviewer name: Debbie
Top Reviewer
Item details
Count per pack: 6
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

KILLS/KEEPS FLEAS OFF

I have a 70lb German Shepherd. I usually get the chew tablet flea medicine for her at the vets. They use to sell Frontline Plus. Now they only sell the chewable tablets. Which are expensive. I decided to go with this brand. I use to always use it. You get 6 tubes of flea medicine for $75. Which is half the price of the flea chew tablets at the vets. Comes out to roughly $12 a tube

Helpful?8b81c8a0-bb12-11f1-becc-af82cebedb1824471380
Nov 1, 2026
Reviewer name: Suzanne
Item details
Count per pack: 3
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

this stuff works better than the prescription treatments.front line takes care of the infestation where all these other pills just kills the aldult flees this one kills all 4 stages very good product wish I knew sooner instead of waisting my money on them prescription treatments.

Helpful?8b81c8a0-bb12-11f1-becc-af82cebedb1824471380
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