Differin Epiduo Pump 1.6oz with Adapalene 0.1% and Benzoyl Peroxide 2.5% Gel
Differin Epiduo Pump 1.6oz with Adapalene 0.1% and Benzoyl Peroxide 2.5% Gel
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Differin Epiduo Pump 1.6oz with Adapalene 0.1% and Benzoyl Peroxide 2.5% Gel

375 ratings
Differin Epiduo Pump 1.6oz with Adapalene 0.1% and Benzoyl Peroxide 2.5% GelDifferin Epiduo Pump 1 6oz with Adapalene 0 1 and Benzoyl Peroxide 2 5 GelDifferin Epiduo Pump 0 5oz with Adapalene 0 1 and Benzoyl Peroxide 2 5 Gel
Size1.6 oz

Key item features

  • RX STRENGTH, DUAL ACTIVE FORMULA: The most effective acne treatment approved by the FDA for use over the counter. The only OTC acne care product combining benzoyl peroxide 2.5% and retinoid adapalene 0.1% gel. FSA/HSA eligible
  • TREATS AND PREVENTS ACNE: Benzoyl peroxide kills bacteria from day 1 while adapalene unclogs pores and prevents future breakouts—together they help clear acne better than single-active alternatives
  • FOR ALL SKIN TYPES: Works for all skin tones and types, including sensitive and oily skin. Helps remove blemishes. Treats clogged pores, blackheads, whiteheads, nodules, papules, and pustules. Face acne treatment, chest acne treatment, and back acne treatment
  • REAL RESULTS FOR RECURRENT ACNE: In one clinical study, Differin Epiduo acne skin care treatment significantly reduced total acne by 65% after 12 weeks. Differin Epiduo treats acne, improving acne-prone skin's overall tone, texture, and radiance

About this item

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Customer ratings & reviews

4.5 out of 5 stars
stars
375 ratings310 reviews
How item rating is calculated
  1. 5 stars73% (273)
  2. 4 stars14% (51)
  3. 3 stars7% (27)
  4. 2 stars3% (12)
  5. 1 star3% (12)

Reviews summary

Pros

  • : The gel absorbs quickly and applies smoothly without greasiness.
  • : The gel soaks in and leaves no greasy residue.
  • : Gel spreads evenly and absorbs quickly without residue.
  • : The formula decreases acne and speeds blemish healing.
  • : The formula emits minimal fragrance and absorbs quickly.

Neutral

  • : Formula absorbs fast but can be hydrating or briefly drying.
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Showing 1-3 of 310 reviews

Oct 4, 2026
Reviewer name: AnyiA
5 out of 5 stars
5 out of 5 stars review

The consistency is key-it take times to see results, but it's worth being patient!

[This review was collected as part of a promotion.] Im really happy with the progress I've seen using Differin Epiduo Acné Gel. The effectiveness has been great, and with consisten application, my skin looks clearer and smoother. The packaging is simple, clean, and easy to use, which I also appreciate for cleanliness and convenience.

Review from differin.com
Helpful?2LM1CCT3LIKV20003354458
Oct 16, 2026
Reviewer name: HallaE
5 out of 5 stars
5 out of 5 stars review

Nice Acne Care Addition! :)

[This review was collected as part of a promotion.] A great addition to my acne care journey! The product was lightweight and easy to put on. Didn't dry out my skin and was useful when I need a hydrating serum along with it! I used it kind of on and off but still feel really good about the improvement of my skin! :)

Review from differin.com
Helpful?2LM1CCT3LIKV20003354458
Oct 3, 2026
Reviewer name: ShilohS
5 out of 5 stars
5 out of 5 stars review

Great for occasional breakouts

[This review was collected as part of a promotion.] Differin epiduo acne gel has helped my acne a ton. I've always struggled with the occasional stress acne. This season in my life has been extremely stressful so I've noticed an occasional pimple here and there. As soon as I see something starting I'll apply the differin gel and by morning the redness has gone down and it is almost completely dried out.

Review from differin.com
Helpful?2LM1CCT3LIKV20003354458
Current price is $34.97$21.86/oz
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