Equate Extra Strength Anti-Itch and Skin Protectant Cream Diphenhydramine HCl 2%, 1 oz, Compare to Extra Strength Benadryl® Cream Active Ingredient
Equate Extra Strength Anti-Itch and Skin Protectant Cream Diphenhydramine HCl 2%, 1 oz, Compare to Extra Strength Benadryl® Cream Active Ingredient
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Equate Extra Strength Anti-Itch and Skin Protectant Cream Diphenhydramine HCl 2%, 1 oz, Compare to Extra Strength Benadryl® Cream Active Ingredient

3,182 ratings
Equate Extra Strength Anti-Itch and Skin Protectant Cream Diphenhydramine HCl 2%, 1 oz, Compare to Extra Strength Benadryl® Cream Active IngredientEquate Extra Strength Anti Itch and Skin Protectant Cream 1 oz3 pack Equate Extra Strength Anti Itch and Skin Protectant Cream 1 oz
Multipack Quantity1

Key item features

  • Active Ingredients: This product contains diphenhydramine hydrochloride 2 percent (topical analgesic) and zinc acetate 0.1 percent (skin protectant), which compares to the active ingredients of Extra Strength Benadryl Itch Stopping Cream
  • Fast Relief: Provides fast relief for most outdoor itches due to bug bites, sunburn and rashes from poison ivy, poison oak or poison sumac
  • Extra Strength Itch Relief: Equate Extra Strength Anti-Itch and Skin Protectant Cream also treats minor skin irritations, such as minor burns, scrapes and cuts
  • Rash Relief: Use Equate Extra Strength Anti-Itch and Skin Protectant Cream on poison ivy, poison oak and poison sumac for fast relief
  • FIRST AID: First aid anti-itch and skin protectant will help to keep you from itching irritated skin

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Customer ratings & reviews

4.6 out of 5 stars
stars
3,182 ratings509 reviews
How item rating is calculated
  1. 5 stars77% (2,438)
  2. 4 stars13% (423)
  3. 3 stars5% (162)
  4. 2 stars2% (48)
  5. 1 star3% (111)

Reviews summary

Pros

  • : Provides great amount at a low cost.
  • : The item is well made and functions reliably.
  • : Relieves itch and calms skin irritations.
  • : Relieves itch and inflammation from rashes.

Neutral

  • : It can be long-lasting and pleasant, or persistently foul.
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Showing 1-3 of 509 reviews

Apr 9, 2026
Reviewer name: Dennis
Top Reviewer
Item details
Multipack quantity: 1
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

This one worked for me!

When i was bed-ridden, I experienced intense itching and this brand was the only one of about 4 anti-itch drugs I tried that actually worked for me! It worked quickly within minutes %26 really stopped the itching. And no super harsh/questionable ingredients like some of the other anti-itch drugs. I went through a great number of these tubes and it always worked.

Helpful?3HZLJPA4B35L228680027
Apr 17, 2025
Reviewer name: jill
Top Reviewer
Item details
Multipack quantity: 1
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

Calms My Itchy Skin, Fantastic ‘Equate Brand!!

nicely because any soap I use??? There's always a chance I'm going to itch! This does it what it says it does with a great price and no smell! skin rubbing against other skin! I'm very fair complected and this works nàcdxdddzfdzfdzfdfdzfddddddzxzddddzxdxzdxzdzxdddzfdzfddzfdzfdzfdfqicely because any soap I use there's always a chance I'm going to itch! It does it what it says it does with a great price and no smell! this cream does what it's supposed to do! It comes my skin from everything from soap irritation to just smaller bug bites! It's a fantastic price at the equate brand is marvelous! to just smaller bug bites! It's a fantastic price at the equate brand is marvelous!

Helpful?3HZLJPA4B35L228680027
Jun 2, 2026
Reviewer name: Maria
Item details
Multipack quantity: 1
5 out of 5 stars
5 out of 5 stars review

Verified Purchase

My granddaughter developed a rash on arm.Send this cream to her,arrived quickly the next. day.She applied it and rash disappeared in 2 days.Would buy and recommend.

Helpful?3HZLJPA4B35L228680027
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