Peptic ulcer is one of the most serious diseases over wide the world. Most classic treatment lines produce adverse drug reactions. Therefore, this study aimed to investigate the protective effects of two natural extracts, namely ginger and marshmallow extracts, on peptic ulcer induced experimentally in rats compared to Famotidine as a reference anti-ulcer agent. In the present study, two different models of animal experiments have been involved. The first was rat pyloric ligation induced gastric ulceration model. The second model of experiments was Indomethacin induced gastric ulceration in rats. Results demonstrate that administration of famotidine, ginger or marshmallow could protect against pyloric ligation and Indomethacin-induced peptic ulcer in rats, being promising for further clinical trials.
