Hero image 0 of Similac Pro-Total Comfort Powder Baby Formula for Delicate Tummies with 2'-FL HMO for Immune Support, 22.5-oz Tub, 0 of 12
Similac Pro-Total Comfort Powder Baby Formula for Delicate Tummies with 2'-FL HMO for Immune Support, 22.5-oz Tub
Key item features
- Partially hydrolyzed whey protein promotes easy digestion
- Our most gentle formula with prebiotic for immune support
- Has DHA and lutein to support brain & eye development
- No palm olein oil supports excellent calcium absorption for strong bones
- Similac is the #1 infant formula brand fed in hospitals
- No artificial growth hormones§ & non-GMO‖
Specs
- Age range0 - 12 Months
- Primary ingredientWater
- Product linePro-Total Comfort HMO
- Rec. useComfort
- Food formPowders
- SizeTrial
Reviews summary
Pros
- : Formula contains ingredients that support immune system development.
- : Formula promotes comfortable digestion.
- : Offers great value for size and quantity.
Neutral
- : Can be gentle, but may cause gassiness in some users.
- : Can reduce gas, but may not work for all or even increase it in some cases.
Generated by AI
Current price is USD$32.68$1.45/oz
Price when purchased online
Not Available
How do you want your item?
Not available
More items to consider
Based on what customers bought
WaterWipes Sensitive Newborn & Baby Wipes, 3-In-1 Cleans, Cares, Protects, 99.9% Water, Unscented & Hypoallergenic, 12 Packs (720 Wipes) $44.97
5 optionsAvailable in additional 5 optionsSponsored$4497current price $44.97More options from $8.47WaterWipes Sensitive Newborn & Baby Wipes, 3-In-1 Cleans, Cares, Protects, 99.9% Water, Unscented & Hypoallergenic, 12 Packs (720 Wipes)
106194.7 out of 5 Stars. 10619 reviewsSave with
Shipping, arrives tomorrowSimilac Pro-Total Comfort Powder Baby Formula, 29.8-oz Value Can $44.98
4 optionsAvailable in additional 4 options$4498current price $44.98Options from $44.98 – $269.88Similac Pro-Total Comfort Powder Baby Formula, 29.8-oz Value Can
22544.4 out of 5 Stars. 2254 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleIn 50+ people's carts Hello Bello Premium Fragrance-Free Baby Wipes, 10 Flip-Top Pouches (600 Total Wipes) $18.97
In 50+ people's carts
2 optionsAvailable in additional 2 optionsSponsored$1897current price $18.97More options from $7.84Hello Bello Premium Fragrance-Free Baby Wipes, 10 Flip-Top Pouches (600 Total Wipes)
28234.6 out of 5 Stars. 2823 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowBest seller Pampers Baby Dry Baby Diapers Size 3, 104 Count (Select for More Options) $29.97
Best seller
27 optionsAvailable in additional 27 options$2997current price $29.97More options from $10.97Pampers Baby Dry Baby Diapers Size 3, 104 Count (Select for More Options)
361064.5 out of 5 Stars. 36106 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowBest seller Parents Choice Fragrance-Free Baby Wipes, 1200 Count (Select for More Options) $23.38
Best seller
5 optionsAvailable in additional 5 options$2338current price $23.38More options from $0.98Parents Choice Fragrance-Free Baby Wipes, 1200 Count (Select for More Options)
469844.7 out of 5 Stars. 46984 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowHuggies Little Snugglers Baby Diapers, Size 5 (27+ lbs), 19 Count (Select for More) $9.94
27 optionsAvailable in additional 27 options$994current price $9.94Options from $9.94 – $74.99Huggies Little Snugglers Baby Diapers, Size 5 (27+ lbs), 19 Count (Select for More)
272204.7 out of 5 Stars. 27220 reviewsSave withShipping, arrives in 2 daysIn 100+ people's carts Huggies Natural Care Cucumber, Aloe and Vitamin E Baby Wipes, Scented, 10 Flip-Top Packs, 560 Total Count (Select for More) $16.97
In 100+ people's carts
3 optionsAvailable in additional 3 optionsSponsored$1697current price $16.97More options from $6.77Huggies Natural Care Cucumber, Aloe and Vitamin E Baby Wipes, Scented, 10 Flip-Top Packs, 560 Total Count (Select for More)
180274.8 out of 5 Stars. 18027 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowHuggies Little Movers Baby Diapers, Size 3 (16-28 lbs), 136 Count $40.88
30 optionsAvailable in additional 30 options$4088current price $40.88More options from $39.97Huggies Little Movers Baby Diapers, Size 3 (16-28 lbs), 136 Count
273144.6 out of 5 Stars. 27314 reviewsShipping, arrives in 3+ daysPampers Cruisers Diapers Size 5, 104 Count (Select for More Options) $69.97
9 optionsAvailable in additional 9 options$6997current price $69.97Options from $69.97 – $74.97Pampers Cruisers Diapers Size 5, 104 Count (Select for More Options)
112064.7 out of 5 Stars. 11206 reviewsShipping, arrives in 3+ daysBest seller Gerber Stage 3 Baby Food Snacks, Mild Cheddar Lil' Crunchies, Baby Led Feeding 1.48 oz $2.97
Best seller
4 optionsAvailable in additional 4 options$297current price $2.97Options from $2.97 – $16.93Gerber Stage 3 Baby Food Snacks, Mild Cheddar Lil' Crunchies, Baby Led Feeding 1.48 oz
35154.7 out of 5 Stars. 3515 reviewsSave withPickup tomorrowDelivery todaySNAP EBT eligibleBest seller Pampers Pure Diapers Size 5, 132 Count (Select for More Options) $65.47
Best seller
19 optionsAvailable in additional 19 options$6547current price $65.47More options from $29.97Pampers Pure Diapers Size 5, 132 Count (Select for More Options)
44514.7 out of 5 Stars. 4451 reviewsSave withShipping, arrives in 3+ daysDr. Brown's Natural Flow Bottle 3-Pack, 8 oz. $30.17
$3017current price $30.17More options from $28.83Dr. Brown's Natural Flow Bottle 3-Pack, 8 oz.
9434.2 out of 5 Stars. 943 reviewsShipping, arrives in 3+ days1000+ bought since yesterday Huggies Simply Clean Unscented Baby Wipes, 3 Pack, 192 Total Count (Select for More) $6.77
1000+ bought since yesterday
3 optionsAvailable in additional 3 options$677current price $6.77Options from $6.77 – $19.47Huggies Simply Clean Unscented Baby Wipes, 3 Pack, 192 Total Count (Select for More)
81094.7 out of 5 Stars. 8109 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowRollback Pampers Sensitive Baby Wipes Unscented, 1 Pack, 56 Total Count (Select for More Options) $2.34
Rollback
6 optionsAvailable in additional 6 options$234current price $2.34Options from $2.34 – $39.97Pampers Sensitive Baby Wipes Unscented, 1 Pack, 56 Total Count (Select for More Options)
250014.8 out of 5 Stars. 25001 reviewsSave withPickup tomorrowDelivery todayBest seller Pampers Swaddlers Overnight Zzz Baby Diapers Size 4, 58 Count (Select for More Options) $29.97
Best seller
7 optionsAvailable in additional 7 options$2997current price $29.97Options from $29.97 – $42.47Pampers Swaddlers Overnight Zzz Baby Diapers Size 4, 58 Count (Select for More Options)
53734.6 out of 5 Stars. 5373 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrow
About this item
Product details
Similac Pro-Total Comfort* is a gentle formula with 2'-FL human milk oligosaccharide† (2'-FL HMO), an immune-nourishing prebiotic like that found‡ in breast milk that supports baby’s developing immune system. It’s an easy-to-digest formula for babies with fussiness, gas, and crying who have difficulty tolerating other milk-based formulas.* Not for infants or children with galactosemia.† Not from human milk.‡ At significant levels.§ No significant difference has been shown between milk derived from rbST-treated and non-rbST-treated cows.‖ Ingredients not genetically engineered.
- Partially hydrolyzed whey protein promotes easy digestion
- Our most gentle formula with prebiotic for immune support
- Has DHA and lutein to support brain & eye development
- No palm olein oil supports excellent calcium absorption for strong bones
- Similac is the #1 infant formula brand fed in hospitals
- No artificial growth hormones§ & non-GMO‖
info:
We aim to show you accurate product information. Manufacturers, suppliers and others provide what you see here, and we have not verified it.
Specifications
Brand
Similac
Age range
0 - 12 Months
Primary ingredient
Water
Product line
Pro-Total Comfort HMO
Directions
Instructions
Directions for Preparation and Use: Your baby's health depends on carefully following these directions. Proper hygiene, handling and storage are important when preparing infant formula. Failure to follow these directions could result in severe harm. Ask your baby's doctor if you need to use cooled, boiled water for mixing and if you need to boil (sterilize) bottles, nipples and rings before use. 1. Wash your hands, surfaces and utensils. Pour water into clean bottle (see mixing guide). 2. Add 1 unpacked level scoop (8.4 g) to each 2 fl oz of water. Return dry scoop to holder in lid. 3. Cap bottle; shake well; attach nipple. Once feeding begins, use within 1 hour or discard. Mixing Guide: Measure water + add scoop(s) of unpacked level powder using enclosed scoop = finished bottle (approx.). 2 fl oz water + 1 scoop (8.4 g) unpacked level powder = approx 2 fl oz finished bottle. 4 fl oz water + 2 scoops unpacked level powder = approx 4 fl oz finished bottle. 6 fl oz water + 3 scoops unpacked level powder = approx 6 fl oz finished bottle. 8 fl oz water + 4 scoops unpacked level powder = approx 8 fl oz finished bottle. For larger size mixing instructions, please visit www.Similac.com/mixinginfo. 1 SimplePac Similac = 42 bottles: 4 fl oz. When mixed as directed, makes approx 170 fl oz of formula. Storage: Once mixed, store bottles in refrigerator and feed to baby within 24 hours. Store unopened or opened container at room temperature; avoid extreme temperatures. Use opened container contents within 1 month. Do not reuse container.
Ingredients
Ingredients
CORN MALTODEXTRIN, WHEY PROTEIN HYDROLYSATE, HIGH OLEIC SAFFLOWER OIL, SUGAR, SOY OIL, COCONUT OIL; LESS THAN 2% OF: SCHIZOCHYTRIUM SP. OIL, M. ALPINA OIL, 2'-FUCOSYLLACTOSE, SHORT-CHAIN FRUCTOOLIGOSAC- CHARIDES, BETA-CAROTENE, LUTEIN, CALCIUM CITRATE, POTASSIUM PHOSPHATE, CALCIUM PHOSPHATE, SALT, MAGNESIUM CHLORIDE, ASCORBIC ACID, CHOLINE CHLORIDE, INOSITOL, POTASSIUM CHLORIDE, SODIUM CITRATE, CALCIUM HYDROXIDE, POTASSIUM CITRATE, CHOLINE BITARTRATE, FERROUS SULFATE, TAURINE, ZINC SULFATE, ASCORBYL PALMITATE, L-CARNITINE, NIACINAMIDE, MIXED TOCOPHEROLS, d-ALPHA-TOCOPHERYL ACETATE, CALCIUM PANTOTHENATE, COPPER SULFATE, VITAMIN A PALMITATE, THIAMINE HYDROCHLORIDE, RIBOFLAVIN, PYRIDOXINE HYDROCHLORIDE, FOLIC ACID, MANGANESE SULFATE, POTASSIUM IODIDE, PHYLLOQUINONE, BIOTIN, SODIUM SELENATE, VITAMIN D3, VITAMIN B12, POTASSIUM HYDROXIDE, AND NUCLEOTIDES (ADENOSINE 5'-MONOPHOSPHATE, CYTIDINE 5'-MONOPHOSPHATE, DISODIUM GUANOSINE 5'-MONOPHOSPHATE, DISODIUM URIDINE 5'-MONOPHOSPHATE), CONTAINS MILK INGREDIENTS.
Warnings
State Chemical Disclosure
None
Popular items in this category
Best selling items that customers love
Similac 360 Total Care Sensitive Baby Formula Powder, Has 5 HMO Prebiotics, 20.1-oz Tub $34.98
4 optionsAvailable in additional 4 options$3498current price $34.98Options from $34.98 – $209.88Similac 360 Total Care Sensitive Baby Formula Powder, Has 5 HMO Prebiotics, 20.1-oz Tub
9784.7 out of 5 Stars. 978 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleSimilac Total Comfort Powder Baby Formula, 12.6-oz Can, Pack of 6 $119.48
$11948current price $119.48Similac Total Comfort Powder Baby Formula, 12.6-oz Can, Pack of 6
834.8 out of 5 Stars. 83 reviewsSave withShipping, arrives in 2 daysSNAP EBT eligibleSimilac Alimentum With 2'-FL HMO, Baby Formula Powder, 12.1-oz Can $38.38
4 optionsAvailable in additional 4 options$3838current price $38.38Options from $38.38 – $230.28Similac Alimentum With 2'-FL HMO, Baby Formula Powder, 12.1-oz Can
20154.3 out of 5 Stars. 2015 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleSimilac Pro-Total Comfort Ready-to-Feed Baby Formula, 32-fl-oz Bottle $9.79
4 optionsAvailable in additional 4 options$979current price $9.79Options from $9.79 – $58.74Similac Pro-Total Comfort Ready-to-Feed Baby Formula, 32-fl-oz Bottle
2594.7 out of 5 Stars. 259 reviewsSave withShipping, arrives tomorrowSNAP EBT eligibleSimilac Alimentum With 2'-FL HMO, Baby Formula Powder, 12.1-oz Can, Pack of 6 $209.00 $4.32/ea
$20900current price $209.00$4.32/eaSimilac Alimentum With 2'-FL HMO, Baby Formula Powder, 12.1-oz Can, Pack of 6
8004.1 out of 5 Stars. 800 reviewsSave withShipping, arrives in 2 daysSNAP EBT eligibleSimilac Total Comfort Powder Baby Formula, 12.6-oz Can $21.58
4 optionsAvailable in additional 4 options$2158current price $21.58Options from $21.58 – $129.48Similac Total Comfort Powder Baby Formula, 12.6-oz Can
25824.6 out of 5 Stars. 2582 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligible100+ bought since yesterday Similac Total Comfort Powder Baby Formula, 29.8-oz Can $38.97
100+ bought since yesterday
4 optionsAvailable in additional 4 options$3897current price $38.97Options from $38.97 – $233.82Similac Total Comfort Powder Baby Formula, 29.8-oz Can
13684.6 out of 5 Stars. 1368 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleSimilac Sensitive Powder Baby Formula, 29.8-oz Can, Pack of 6 $232.82
4 optionsAvailable in additional 4 options$23282current price $232.82More options from $77.94Similac Sensitive Powder Baby Formula, 29.8-oz Can, Pack of 6
49244.6 out of 5 Stars. 4924 reviewsSave withShipping, arrives in 2 daysSNAP EBT eligibleSimilac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 32-fl-oz Bottle $11.48
4 optionsAvailable in additional 4 options$1148current price $11.48Options from $11.48 – $68.88Similac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 32-fl-oz Bottle
9394.7 out of 5 Stars. 939 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleSimilac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 8-fl-oz Bottle, Pack of 6 $19.98
4 optionsAvailable in additional 4 options$1998current price $19.98Options from $19.98 – $119.88Similac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 8-fl-oz Bottle, Pack of 6
8414.7 out of 5 Stars. 841 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleSimilac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 8-fl-oz Bottle, Pack of 24 $71.88 37.4 ¢/fl oz
$7188current price $71.8837.4 ¢/fl ozSimilac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 8-fl-oz Bottle, Pack of 24
4224.7 out of 5 Stars. 422 reviewsSave withShipping, arrives in 3+ daysSNAP EBT eligible100+ bought since yesterday Similac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 2-fl-oz Bottle, Pack of 12 $9.88
100+ bought since yesterday
4 optionsAvailable in additional 4 options$988current price $9.88Options from $9.88 – $59.28Similac 360 Total Care Sensitive Ready-to-Feed Baby Formula, Has 5 HMO Prebiotics, 2-fl-oz Bottle, Pack of 12
8594.7 out of 5 Stars. 859 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligible100+ bought since yesterday Similac Sensitive Powder Baby Formula, 12.5-oz Can $21.28
100+ bought since yesterday
2 optionsAvailable in additional 2 options$2128current price $21.28Options from $21.28 – $42.56Similac Sensitive Powder Baby Formula, 12.5-oz Can
46934.6 out of 5 Stars. 4693 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligible100+ bought since yesterday Similac Alimentum With 2'-FL HMO, Ready-to-Feed Baby Formula, 8-fl-oz Can, Pack of 6 $15.88
100+ bought since yesterday
4 optionsAvailable in additional 4 options$1588current price $15.88Options from $15.88 – $95.28Similac Alimentum With 2'-FL HMO, Ready-to-Feed Baby Formula, 8-fl-oz Can, Pack of 6
8644.6 out of 5 Stars. 864 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleSimilac Alimentum With 2'-FL HMO, Ready-to-Feed Baby Formula, 8-fl-oz Can, Pack of 24 $63.52 $2.65/ea
$6352current price $63.52$2.65/eaSimilac Alimentum With 2'-FL HMO, Ready-to-Feed Baby Formula, 8-fl-oz Can, Pack of 24
7884.1 out of 5 Stars. 788 reviewsSave withShipping, arrives in 2 daysSNAP EBT eligibleSimilac Sensitive Powder Baby Formula, 12.5-oz Can, Pack of 6 $119.68 $9.97/fl oz
$11968current price $119.68$9.97/fl ozSimilac Sensitive Powder Baby Formula, 12.5-oz Can, Pack of 6
15054.5 out of 5 Stars. 1505 reviewsSave withShipping, arrives in 2 daysSNAP EBT eligibleSimilac Sensitive Ready-to-Feed Baby Formula, 32-fl-oz Bottle $9.18
4 optionsAvailable in additional 4 options$918current price $9.18Options from $9.18 – $55.08Similac Sensitive Ready-to-Feed Baby Formula, 32-fl-oz Bottle
20474.6 out of 5 Stars. 2047 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligibleEnfamil NeuroPro Gentlease Baby Formula for Easing Fussiness, Gas, Spit-up in 24 Hrs, 27.4 oz Can $52.00
4 optionsAvailable in additional 4 options$5200current price $52.00Options from $52.00 – $208.00Enfamil NeuroPro Gentlease Baby Formula for Easing Fussiness, Gas, Spit-up in 24 Hrs, 27.4 oz Can
98934.6 out of 5 Stars. 9893 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowSNAP EBT eligible
Customer ratings & reviews
How item rating is calculated
Reviews summary
Pros
- : Formula contains ingredients that support immune system development.
- : Formula promotes comfortable digestion.
- : Offers great value for size and quantity.
Neutral
- : Can be gentle, but may cause gassiness in some users.
- : Can reduce gas, but may not work for all or even increase it in some cases.
Generated by AI
Customer images
+5 images
Sort by |
Showing 1-3 of 756 reviews
Nov 21, 2021
rachelb
5 out of 5 stars review
Seller Verified Purchase
Great Quality and Excellent Price
Formula often gets negative reviews simply because it's not the right one for your baby!! I have twins with severe silent reflux, the ended up on Alimentum RTF which is fully hydrolocized. Total Comfort is partially hydrolocized - so as the boys have weaned off their reflux medication we've been able to switch to this with great success! Remember parents - IT TAKE 2 FULL WEEKS ON ANY FORMULA TO SEE TRUE RESULTS. Too many parents jump from one formula to another and it's extremely hard on your little ones GI system and you'll never see results.
Review from samsclub.com
Helpful?373SXG6OUMCH191100634
Jul 15, 2025
topangablake_9495
5 out of 5 stars review
Need to have
[This review was collected as part of a promotion.] We absolutely adore this product. Packaging is great very informative. Texture is just as any formula you do not need to mix with water. Ingredients are great for your infant. Once open you do need to refrigerate and all must be used within three days. This is great for on the go on vacation or a day over at the grandparents.
Review from influenster.com
Helpful?373SXG6OUMCH191100634
Jul 30, 2025
arcukae_1707
5 out of 5 stars review
So convenient!
[This review was collected as part of a promotion.] We love the gentler formulas offered by Similac, and it's so convenient to have the formula in a ready-to-feed form. It's especially helpful on trips or with those sleepless newborn nights when I have no desire to measure out scoops of powdered formula.
Review from influenster.com
Helpful?373SXG6OUMCH191100634
Related pages
- Reguline Formula
- Similac Cans
- Enfamil Water
- Similac Milk
- Similac Sensitive Formula
- Similase Gfcf
- Similac Routine Baby Formula (Advance, Pro-Advance, Supplementation)
- Enfamil Specialty Liquids
- Similac Baby Formula
- Enfamil Baby Formula
- Enfamil Gentlease, A.R., Reguline, ProSobee, Soy Ready to Use Liquids
- Enfamil Infant Liquid