Enfamil Optimum (Enspire) Powder Baby Formula, Our Closest to Breast Milk, 30 oz Refill
Enfamil Optimum (Enspire) Powder Baby Formula, Our Closest to Breast Milk, 30 oz Refill
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Enfamil Optimum (Enspire) Powder Baby Formula, Our Closest to Breast Milk, 30 oz Refill

Key item features

  • NEW LOOK, SAME PREMIUM NUTRITION: Previously known as Enspire Optimum, Enfamil Optimum Baby Formula now has a refreshed look and name while offering the same trusted infant nutrition parents rely on.
  • OUR CLOSEST FORMULA TO BREAST MILK: Enfamil Optimum is the first and only leading baby formula to include lactoferrin, a key immune-supporting protein found in colostrum and breastmilk.
  • SUPPORTS IMMUNE & BRAIN DEVELOPMENT: This premium formula includes lactoferrin, a dual prebiotic blend (2'FL & LnNT), and brain-building DHA—all clinically-tested ingredients.
  • COMPLETE NUTRITION FOR DAILY FEEDINGS: A great choice for everyday formula use, this 30 oz tub of Enfamil Optimum provides complete nutrition in a convenient powder format—perfect for full-time feeding or supplementing breast milk.
  • TRUSTED NUTRITION FOR COMBO FEEDING: With key nutrients for growing babies, Enfamil Optimum gives parents the flexibility to supplement breastfeeding with our closest formula to breast milk.
  • NO ARTIFICIAL ADDITIVES & NON-GMO: Has clinically-tested, non-GMO ingredients. Free from artificial growth hormones, colors, and flavors. Enfamil Optimum does not contain high fructose corn syrup and is made with milk sourced from the United States. Optimum is premium baby formula for infants through 12 months of age.
  • PEDIATRICIAN & PARENT TRUSTED: Enfamil is the #1 trusted infant formula brand by pediatricians* and parents, making Optimum baby formula a reliable choice for growing families.
  • JOIN ENFAMIL FAMILY BEGINNINGS® & EARN REWARDS: Sign up for Enfamil Family Beginnings® to enjoy exclusive savings, expert tips, and personalized support—plus earn rewards with every eligible purchase. 
  • CHOOSE A CASE PACK FOR ADDED CONVENIENCE: Stock up with a case pack of Enfamil formula to help ensure you’re always prepared—ideal for regular feedings and busy routines.
Current price is $60.49$2.02/oz
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Customer ratings & reviews

4.8 out of 5 stars
stars3,794 ratings3,358 reviews
How item rating is calculated
4.9
5.0
4.9
4.7
4.5
0.8

Reviews summary

Pros

  • : Formula's composition mimics breast milk's nutrients.
  • : Works as a supplement to breast milk without causing issues.
  • : Similar in consistency and composition to breast milk.
  • : Formula is easy to digest.
  • : Reduces spit-up in most babies.

Cons

  • : Formula's high price outweighs its benefits for some users.
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Showing 1-3 of 3,358 reviews

Apr 24, 2026
Lj
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Count: 1
5 out of 5 stars review

Verified Purchase

Our baby loves his formula, as he should. We feel blessed to be able to provide formula as close to breast milk as possible. It's nutritious and easy on his stomach. I don't think you will be disappointed with this formula. We have used both the ready to serve formula and the powdered %26 were pleased with both! I only wish we could get coupons because ALL formula is expensive (for us anyway). We didn't get ANY kind of samples from the hospital because of breastfeeding at the time, %26 haven't been able to get samples or coupons since. But we will continue regardless to use this formula because it is the very best for our baby!!

Helpful?3f30f110-0885-11f0-b990-837696d08059519633740
Nov 16, 2025
Roger
Item details
Count: 1
5 out of 5 stars review

Verified Purchase

I was initially worried if the extra bells and whistles were just a marketing strategy but the studies done on babies who received these components vs those who didn't do not lie. My baby also went from thick green stool on Gentlease to breastfed yellow stool on this. It really is the closest to breastmilk you can get.

Helpful?3f30f110-0885-11f0-b990-837696d08059519633740
reply from Enfamil Team

Hi Roger! Thank you for choosing Enfamil® Enspire™ Optimum™! We appreciate your feedback and would like to learn more about your child's experience using our formula. Please give us a call at 1-800-222-9123, choose option 1 and reference #8133122. Thanks! Hazel -Enfamil Expert

Apr 4, 2026
Holly
Item details
Count: 1
5 out of 5 stars review

Verified Purchase

Best of the best

When the product I had chosen was recalled, I switched to Enfamil Optimum and was so happy with how my daughter took it. It mixes really well with tap or hot water. I hope more brands keep incorporating advanced ingredients like lactoferrin. The Walmart subscription makes it a convenient option too.

Helpful?3f30f110-0885-11f0-b990-837696d08059519633740