Hero image 0 of THORNE - Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports methylation & Healthy Level of homocysteine* - Gluten, Dairy & Soy-Free - 90 Capsules, 0 of 9
THORNE - Methyl-Guard Plus - Active folate (5-MTHF) with Vitamins B2, B6 & B12 - Supports methylation & Healthy Level of homocysteine* - Gluten, Dairy & Soy-Free - 90 Capsules
Key item features
- Healthy Methylation: Methyl-Guard Plus supports methylation and promotes a healthy level of homocysteine
- Active Forms: Formulated with active folate (5-MTHF) and the active, tissue-ready forms of vitamins B2, B6, and B12 to optimize absorption
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health
- Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)
Specs
- Vitamin & supplement typeVitamin Supplements
- Primary ingredientVitamin B-Complex, Folate
- Health concernHeart Health, General Health & Wellness
- Serv per cont30
- Serving size3 Capsules
- Enteral medication formCapsules
Current price is USD$62.00
Price when purchased online
- Free shipping
Free 90-day returns
Subscribe, Your usuals, on your schedule, Save time and stay stocked!, $62.00
Subscribe
$62.00
Your usuals, on your schedule
Save time and stay stocked!
One-time purchase $62.00
One-time purchase
$62.00
How do you want your item?
Try 30 days of Free Shipping with Walmart+! Choose plan at checkout.
Columbus, 43215
Arrives by Tomorrow
.Order within 43 min
Sold by Pattern|Pro Seller
Fulfilled by Walmart
4.6758882309400445 stars out of 5, based on 10834 seller reviews(4.7)10834 seller reviews
Free 90-day returns
About this item
Product details
More concentrated methylation support. Since 1984, Thorne has set the standard for the exceptional formulation and quality manufacturing of nutritional supplements. Thorne delivers premium, science-based products, a health diagnostics technology platform, and the latest in medical education. With more than 350 products, Thorne is the most dispensed brand by 30-to 40-year-old health-care practitioners. Thorne is dedicated to improving the health of our community as well as increasing the knowledge of nutritional health and wellness. Since 2012, Thorne has partnered with educational institutes and local charities to donate more than 1M in products and profits.Thorne products do not contain any unnecessary binders, coatings, disintegrants, fillers, or lubricants (including magnesium stearate) that could impair absorption. Thorne adheres to the current Good Manufacturing Practices (cGMPs) and has the highest number of NSF Certified for Sport products which test for more than 200 banned substances for elite athletic competitions.
- Healthy Methylation: Methyl-Guard Plus supports methylation and promotes a healthy level of homocysteine
- Active Forms: Formulated with active folate (5-MTHF) and the active, tissue-ready forms of vitamins B2, B6, and B12 to optimize absorption
- Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health
- Free From: Doesn't contain gluten, eggs, tree nuts, peanuts, dairy, soy, fish, or shellfish
- Trusted: Thorne is chosen by champions and trusted by 100+ professional sports teams, a proud partner of U.S. National Teams, and the #1 recommended clinical brand by health-care practitioners (2023 Health-Care Practitioner Seller Survey)
info:
We aim to show you accurate product information. Manufacturers, suppliers and others provide what you see here, and we have not verified it.
Specifications
Brand
Thorne
Size
90 Capsules
Enteral medication form
Capsules
Primary ingredient
Vitamin B-Complex, Folate
Indications
Stop Use Indications
If pregnant, consult your health-care practitioner before using this product. 5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Health Concern
Heart Health General Health & Wellness
Skin Care Concern
Dryness
Directions
Dosage
Take 1-3 capsules daily or as recommended by a healthcare practitioner.
Warranty
Warranty information
None
Please be aware that the warranty terms on items offered for sale by third party Marketplace sellers may differ from those displayed in this section (if any). To confirm warranty terms on an item offered for sale by a third party Marketplace seller, please use the 'Contact seller' feature on the third party Marketplace seller's information page and request the item's warranty terms prior to purchase.
Please be aware that the warranty terms on items offered for sale by third party Marketplace sellers may differ from those displayed in this section (if any). To confirm warranty terms on an item offered for sale by a third party Marketplace seller, please use the 'Contact seller' feature on the third party Marketplace seller's information page and request the item's warranty terms prior to purchase.
Ingredients
Inactive Ingredients
Riboflavin (as Riboflavin 5Phosphate Sodium) 90 mg, Vitamin B6 (as Pyridoxal 5Phosphate) 45 mg, Folate (as L5Methyltetrahydrofolate from L5Methyltetrahydrofolic Acid, Glucosamine Salt) 3 mg, Vitamin B12 (as Methylcobalamin) 3 mg, Betaine Anhydrous (Trimethylglycine) 1.8 g
Ingredients
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg, Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg, Folate (3 mg as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 5 mg DFE, Vitamin B12 (as Methylcobalamin) 3 mg, Betaine Anhydrous (Trimethylglycine) 1.8 g Other Ingredients: Hypromellose (derived from cellulose) capsule, Calcium Citrate, Calcium Laurate.
Active Ingredients
Riboflavin (as Riboflavin 5'-Phosphate Sodium) 90 mg, Vitamin B6 (as Pyridoxal 5'-Phosphate) 45 mg, Folate (as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 3 mg, Vitamin B12 (as Methylcobalamin) 3 mg, Betaine Anhydrous (Trimethylglycine) 1.8 g
Warnings
Warning Text
safety:The statements made herein have not been evaluated by the Food and Drug Administration. Products are not intended to diagnose, treat, cure, or prevent disease. If you have any concerns about your own health, you should always consult with a physician or other healthcare professional.
Similar items you might like
Based on what customers bought
THORNE - Methyl-Guard - Methylation Support Supplement* with Folate and Vitamin B12 - 180 Capsules $56.00
$5600current price $56.00THORNE - Methyl-Guard - Methylation Support Supplement* with Folate and Vitamin B12 - 180 Capsules
364.4 out of 5 Stars. 36 reviewsTHORNE - Vitamin C 500 mg - Blend of Vitamin C and Citrus Bioflavonoids from Oranges - Supports Immune System* - Third-Party Certified - 90 Servings $23.00
$2300current price $23.00THORNE - Vitamin C 500 mg - Blend of Vitamin C and Citrus Bioflavonoids from Oranges - Supports Immune System* - Third-Party Certified - 90 Servings
1144.9 out of 5 Stars. 114 reviews100+ bought since yesterday Nature's Bounty Vitamin D3 125 mcg 5000 IU Softgels, Immune & Bone Health Support, High Potency Supplement, 150 Count $9.97 6.6 ¢/count
100+ bought since yesterday
2 optionsAvailable in additional 2 optionsSponsored$997current price $9.976.6 ¢/countNature's Bounty Vitamin D3 125 mcg 5000 IU Softgels, Immune & Bone Health Support, High Potency Supplement, 150 Count
12624.8 out of 5 Stars. 1262 reviewsTHORNE - Stress B-Complex - Vitamins B2, B6, B12, and Folate in Highly-Absorbable and Active Forms - Extra Vitamin B5 for Adrenal Support, Stress Management and Immune Function* - 60 Capsules $26.00
$2600current price $26.00THORNE - Stress B-Complex - Vitamins B2, B6, B12, and Folate in Highly-Absorbable and Active Forms - Extra Vitamin B5 for Adrenal Support, Stress Management and Immune Function* - 60 Capsules
1054.8 out of 5 Stars. 105 reviewsTHORNE - Basic B-Complex - Tissue-Ready Vitamin B Complex Supplement with Choline - Supports Cellular Energy Production, Brain Health, Red Blood Cell Formation* - Gluten & Dairy-Free - 60 Capsules $27.00
$2700current price $27.00THORNE - Basic B-Complex - Tissue-Ready Vitamin B Complex Supplement with Choline - Supports Cellular Energy Production, Brain Health, Red Blood Cell Formation* - Gluten & Dairy-Free - 60 Capsules
1534.8 out of 5 Stars. 153 reviewsTHORNE - Niacinamide - 500mg Niacin - Non-Flushing Form of Vitamin B3 - Support Joint Health, Skin Health & Restful Sleep* - Gluten-Free - 180 Capsules $26.00
$2600current price $26.00THORNE - Niacinamide - 500mg Niacin - Non-Flushing Form of Vitamin B3 - Support Joint Health, Skin Health & Restful Sleep* - Gluten-Free - 180 Capsules
334.6 out of 5 Stars. 33 reviewsMethyl B12 60ct by Ortho Molecular Products $45.00
$4500current price $45.00Methyl B12 60ct by Ortho Molecular Products
33.7 out of 5 Stars. 3 reviewsTHORNE - B-Complex #12 - Vitamin B Complex with Active B12 and Folate - 60 Capsules $26.00
$2600current price $26.00THORNE - B-Complex #12 - Vitamin B Complex with Active B12 and Folate - 60 Capsules
974.8 out of 5 Stars. 97 reviewsTHORNE - B-Complex #6 - Vitamin B Complex with Active Forms of Essential B Vitamins and Extra B6 - 60 Capsules $26.00
$2600current price $26.00THORNE - B-Complex #6 - Vitamin B Complex with Active Forms of Essential B Vitamins and Extra B6 - 60 Capsules
604.9 out of 5 Stars. 60 reviewsMoxyVites Vitamin B Complex Methylfolate (L-5-MTHF) Methyl B12 & B6 - Neurological Health, Cardiovascular Health - 120 Vegan Capsules $23.95
5 optionsAvailable in additional 5 options$2395current price $23.95MoxyVites Vitamin B Complex Methylfolate (L-5-MTHF) Methyl B12 & B6 - Neurological Health, Cardiovascular Health - 120 Vegan Capsules
6544.7 out of 5 Stars. 654 reviewsNOW Supplements, Methyl B-12 (Methylcobalamin) 5,000 mcg, Nervous System Health*, 120 Lozenges $24.99 20.8 ¢/count
$2499current price $24.9920.8 ¢/countNOW Supplements, Methyl B-12 (Methylcobalamin) 5,000 mcg, Nervous System Health*, 120 Lozenges
104.5 out of 5 Stars. 10 reviewsPure Encapsulations MethylAssist 90's - B Vitamin Complex - Methylation Support* - Heart Health & Brain Health - Non-GMO & Gluten Free - 90 Capsules $64.00
$6400current price $64.00Pure Encapsulations MethylAssist 90's - B Vitamin Complex - Methylation Support* - Heart Health & Brain Health - Non-GMO & Gluten Free - 90 Capsules
144.5 out of 5 Stars. 14 reviewsTHORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 5mg $68.00
$6800current price $68.00THORNE - 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels* - 60 Capsules - 5-MTHF 5mg
65 out of 5 Stars. 6 reviewsReduced price MaryRuth's Vegan Vitamin B Complex Liquid Drops, Cherry Flavor, Non-GMO, USDA Organic, 1 fl $23.96 Was $29.95
Reduced price
$2396current price $23.96, Was $29.95$29.95MaryRuth's Vegan Vitamin B Complex Liquid Drops, Cherry Flavor, Non-GMO, USDA Organic, 1 fl
17144.8 out of 5 Stars. 1714 reviewsBronson Vitamin B Complex (Vitamin B1, B2, B3, B6, B9 - Folic Acid, B12), 100 Tablets $14.99 Was $21.38
2 optionsAvailable in additional 2 options$1499current price $14.99, Was $21.38$21.38Bronson Vitamin B Complex (Vitamin B1, B2, B3, B6, B9 - Folic Acid, B12), 100 Tablets
764.5 out of 5 Stars. 76 reviewsLife Extension Optimized Folate L-Methylfolate 1700 Mcg DFE, Folic Acid Supplement, Cognitive Health, Cardiovascular Health, 100 Vegetarian Tablets $11.25 11.3 ¢/count
$1125current price $11.2511.3 ¢/countLife Extension Optimized Folate L-Methylfolate 1700 Mcg DFE, Folic Acid Supplement, Cognitive Health, Cardiovascular Health, 100 Vegetarian Tablets
2284.8 out of 5 Stars. 228 reviewsSolaray Methyl B-Complex 50mg | Methylated Forms of Folate & B-12 | Healthy Hair & Skin, Nerves, Immune Function & Metabolism Support | 60 VegCaps $33.29
$3329current price $33.29Solaray Methyl B-Complex 50mg | Methylated Forms of Folate & B-12 | Healthy Hair & Skin, Nerves, Immune Function & Metabolism Support | 60 VegCaps
1974.7 out of 5 Stars. 197 reviews4-in-1 Calcium Supplements, with 5000 IU D3 K2 (MK7) Vitamin B12 for Heart,Bone,Immune,120 Capsules $13.99
4 optionsAvailable in additional 4 options$1399current price $13.994-in-1 Calcium Supplements, with 5000 IU D3 K2 (MK7) Vitamin B12 for Heart,Bone,Immune,120 Capsules
2964.6 out of 5 Stars. 296 reviewsMethyl B-12 5,000 mcg - 60 Lozenges $15.99
$1599current price $15.99Methyl B-12 5,000 mcg - 60 Lozenges
164.9 out of 5 Stars. 16 reviewsMaryRuth's Vitamin D3 B12 Gummies Bone Health & Immune Support Sugar Free Vegan Raspberry 60 Gummies $26.95
3 optionsAvailable in additional 3 options$2695current price $26.95MaryRuth's Vitamin D3 B12 Gummies Bone Health & Immune Support Sugar Free Vegan Raspberry 60 Gummies
29814.9 out of 5 Stars. 2981 reviews
Check out these related products
THORNE - Vitamin B12 - as Methylcobalamin - Supports Heart & Nerve Health, Blood Cell Function, Healthy Sleep & Methylation* - Gluten, Dairy & Soy-Free - 60 Capsules $24.00
$2400current price $24.00THORNE - Vitamin B12 - as Methylcobalamin - Supports Heart & Nerve Health, Blood Cell Function, Healthy Sleep & Methylation* - Gluten, Dairy & Soy-Free - 60 Capsules
1094.7 out of 5 Stars. 109 reviewsTHORNE - Vitamin K2 Liquid (1 mg per drop) - Concentrated Vitamin K2 Supplement for Heart and Bone Support* - 1 Fl Oz $75.00
$7500current price $75.00THORNE - Vitamin K2 Liquid (1 mg per drop) - Concentrated Vitamin K2 Supplement for Heart and Bone Support* - 1 Fl Oz
164 out of 5 Stars. 16 reviewsTHORNE - Ultimate-E - Contains All of the Natural Forms of Vitamin E - 60 Gelcaps $58.00
$5800current price $58.00THORNE - Ultimate-E - Contains All of the Natural Forms of Vitamin E - 60 Gelcaps
214.7 out of 5 Stars. 21 reviewsTHORNE - Advanced Bone Support‡ - (Formerly Oscap) - Bone Health Supplement with Calcium and Vitamin D* - 120 Capsules $29.00
$2900current price $29.00THORNE - Advanced Bone Support‡ - (Formerly Oscap) - Bone Health Supplement with Calcium and Vitamin D* - 120 Capsules
444.7 out of 5 Stars. 44 reviewsTHORNE - Vitamin C 1,000 mg (formerly Ascorbic Acid) Supplement - Supports Healthy Immune Function - Provides Antioxidant Support* - 60 Servings $19.00
$1900current price $19.00THORNE - Vitamin C 1,000 mg (formerly Ascorbic Acid) Supplement - Supports Healthy Immune Function - Provides Antioxidant Support* - 60 Servings
163.9 out of 5 Stars. 16 reviewsTHORNE - Red Yeast Rice (formerly Choleast-900) - Supports Healthy Cholesterol Levels Already in a Normal Range, Heart Health & Blood Pressure* - Gluten-Free, Dairy-Free - 120 Capsules $56.00 $56.00/120
$5600current price $56.00$56.00/120THORNE - Red Yeast Rice (formerly Choleast-900) - Supports Healthy Cholesterol Levels Already in a Normal Range, Heart Health & Blood Pressure* - Gluten-Free, Dairy-Free - 120 Capsules
474.8 out of 5 Stars. 47 reviewsTHORNE - Calcium - (formerly DiCalcium Malate) - Chelated Calcium for Enhanced Absorption with DimaCal for Bone Density Support* - 120 Capsules $28.00
$2800current price $28.00THORNE - Calcium - (formerly DiCalcium Malate) - Chelated Calcium for Enhanced Absorption with DimaCal for Bone Density Support* - 120 Capsules
434.6 out of 5 Stars. 43 reviewsTHORNE - Red Yeast Rice CoQ10 - Maintain Healthy Cholesterol Levels and Supports Cardiovascular Health* - Gluten-Free, Dairy-Free - 120 Capsules $46.00
$4600current price $46.00THORNE - Red Yeast Rice CoQ10 - Maintain Healthy Cholesterol Levels and Supports Cardiovascular Health* - Gluten-Free, Dairy-Free - 120 Capsules
554.5 out of 5 Stars. 55 reviewsTHORNE - Advanced Nutrients - Multivitamin and Mineral Supplement with Nicotinamide Riboside Hydrogen Malate - Foundational Support, Healthy Aging and Eye Health* - 240 Capsules - 30 Servings $72.00
$7200current price $72.00THORNE - Advanced Nutrients - Multivitamin and Mineral Supplement with Nicotinamide Riboside Hydrogen Malate - Foundational Support, Healthy Aging and Eye Health* - 240 Capsules - 30 Servings
824.5 out of 5 Stars. 82 reviewsTHORNE - Thyroid Health Complex (formerly Thyrocsin) - Thyroid Function Support* - Vitamins B12, C & E, Ashwagandha, Iodine, & Selenium - 60 Servings $40.00
$4000current price $40.00THORNE - Thyroid Health Complex (formerly Thyrocsin) - Thyroid Function Support* - Vitamins B12, C & E, Ashwagandha, Iodine, & Selenium - 60 Servings
484.8 out of 5 Stars. 48 reviewsTHORNE - Stress Balance (Formerly Phytisone) - Adrenal Support Supplement with Vitamin C & Ashwagandha - Dairy-Free Health Support* - 60 Capsules - 30 Servings $23.00
$2300current price $23.00THORNE - Stress Balance (Formerly Phytisone) - Adrenal Support Supplement with Vitamin C & Ashwagandha - Dairy-Free Health Support* - 60 Capsules - 30 Servings
434.7 out of 5 Stars. 43 reviewsTHORNE - Advanced Iron Complex (formerly Ferrasorb) - Complete Blood Support Formula* - B and C Vitamins for Optimal Absorption - 60 Servings $26.00
$2600current price $26.00THORNE - Advanced Iron Complex (formerly Ferrasorb) - Complete Blood Support Formula* - B and C Vitamins for Optimal Absorption - 60 Servings
1724.8 out of 5 Stars. 172 reviewsTHORNE - Trace Minerals - Dietary Supplement with Zinc, Boron & Selenium - Chelated Forms - Comprehensive Formula - 90 Capsules $24.00
$2400current price $24.00THORNE - Trace Minerals - Dietary Supplement with Zinc, Boron & Selenium - Chelated Forms - Comprehensive Formula - 90 Capsules
174.8 out of 5 Stars. 17 reviewsTHORNE - Magnesium CitraMate - Magnesium Supplement with Citrate-Malate - Support Heart, Skeletal Muscles, Cardiac, Lung Function, and Bone Density* - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules $22.00
$2200current price $22.00THORNE - Magnesium CitraMate - Magnesium Supplement with Citrate-Malate - Support Heart, Skeletal Muscles, Cardiac, Lung Function, and Bone Density* - Gluten-Free, Dairy-Free, Soy-Free - 90 Capsules
2324.9 out of 5 Stars. 232 reviewsTHORNE - Phytoprofen - Botanical Blend of Ginger, Boswellia, and Curcumin - Supports Healthy Cytokine Balance and Recovery After Injury or Surgery* - Gluten-Free, Soy-Free, Dairy-Free - 60 Capsules $41.00
$4100current price $41.00THORNE - Phytoprofen - Botanical Blend of Ginger, Boswellia, and Curcumin - Supports Healthy Cytokine Balance and Recovery After Injury or Surgery* - Gluten-Free, Soy-Free, Dairy-Free - 60 Capsules
224.5 out of 5 Stars. 22 reviewsTHORNE - Iron Bisglycinate - 25 mg Iron Supplement for Enhanced Absorption Without Gastrointestinal Side Effects* - NSF Certified for Sport - Gluten-Free - 60 Capsules $16.00 $94.12/lb
$1600current price $16.00$94.12/lbTHORNE - Iron Bisglycinate - 25 mg Iron Supplement for Enhanced Absorption Without Gastrointestinal Side Effects* - NSF Certified for Sport - Gluten-Free - 60 Capsules
1844.8 out of 5 Stars. 184 reviews
Customer ratings & reviews
How item rating is calculated
Filtered and sorted results would be available on the new 'Customer ratings & reviews' page.
Sort by |
Showing 1-3 of 80 reviews
Dec 23, 2025
J
5 out of 5 stars review
Verified Purchase
Recommend Highly
Seller is Excellent. Product is just what my doctor ordered. Excellent Product %26 Seller. Will BUY AGAIN %26 I Highly recommended THORNE - Methyl-Guard Plus - Active folate (5-MTHF) to others. Tolerate this product well, no taste or fizziness.
Incentivized Review
Helpful?6ZFU6103YF6O148311295
Jun 9, 2025
mary
5 out of 5 stars review
Verified Purchase
Because of MTHFR gene differenial, I must take methylated B vitamin complex 2x day per neuro doc. i have tried many brands over many years. in my humble opinion, Thorne digests easiest, thereby providing me w said B vitamins.
Helpful?6ZFU6103YF6O148311295
Jan 29, 2026
Elaine
5 out of 5 stars review
Verified Purchase
The recipient of my gift was very happy with the quality
Incentivized Review
Helpful?6ZFU6103YF6O148311295
