Hero image 0 of Prilosec OTC 24 Hour, Omeprazole Delayed-Release Tablets, 20mg Acid Reducer, 42 Tablets (3 Pack of 14 Tablets), 0 of 12
Prilosec OTC 24 Hour, Omeprazole Delayed-Release Tablets, 20mg Acid Reducer, 42 Tablets (3 Pack of 14 Tablets)
Key item features
- TREATS FREQUENT HEARTBURN: Heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN
- REDUCES EXCESS ACID PRODUCTION for heartburn relief all day and all night. Starts reducing acid on DAY 1*
- ACTIVE INGREDIENT: Each pill contains 20mg of Omeprazole, an acid reducer that provides long-lasting, 24-hour heartburn relief*
- #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible**
- OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine
- SATISFACTION GUARANTEED or your money back
Specs
- Over-the-counter medicine typeAcid Reducer
- Health concernAcid Reflux
- Active ingredientsOmeprazole
- Medicine strength20mg
- Dosage1
- Product lineOTC
Reviews summary
Pros
- : Relieves heartburn for 24 hours.
- : Offers lower cost compared to others.
- : Helps manage stomach acid production.
Generated by AI
More seller options (1)
Starting from $38.25
About this item
Product details
With Prilosec OTC, you can take control of heartburn. If you suffer from frequent heartburn, there's no need to stash antacids everywhere for whenever heartburn might strike. With Prilosec OTC, you can take 1 PILL A DAY for 24 HOURS of ZERO HEARTBURN.* Prilosec OTC is the first and original over-the-counter frequent heartburn (defined as occurring 2 or more times per week) medicine. The active ingredient in Prilosec OTC is omeprazole magnesium delayed-release tablet 20mg (equivalent to 20.6mg omeprazole), which is part of a class of medications called proton pump inhibitors, or PPIs. PPIs reduce stomach acid production by shutting down many of the pumps in the stomach that produce acid. In other words, Prilosec OTC blocks acid production at its source, so you don't get heartburn in the first place.* Take Prilosec OTC once a day and use as directed for 14 days to treat frequent heartburn. Prilosec OTC may take 1-4 days for full effect. Prilosec OTC is the #1 Doctor, Gastroenterologist^ and Pharmacist^^ recommended OTC frequent heartburn medicine.*It's possible while taking Prilosec OTC. Use as directed for 14 days to treat frequent heartburn. May take 1-4 days for full effect.P&G Calculation based in part on Buying Households reported by the Nielsen Company through its Homescan Panel service in the US for Prilosec OTC for the period of 8/31/03 through 6/25/16.^IQVIA ProVoice Survey, Jan 2005 - Mar 2018^^Pharmacy Times Surveys, Acid Reducer/Heartburn Categories 2006-2018
- TREATS FREQUENT HEARTBURN: Heartburn medicine for those who experience heartburn 2+ times a week. With just 1 PILL each morning, experience 24 HOURS with ZERO HEARTBURN
- REDUCES EXCESS ACID PRODUCTION for heartburn relief all day and all night. Starts reducing acid on DAY 1*
- ACTIVE INGREDIENT: Each pill contains 20mg of Omeprazole, an acid reducer that provides long-lasting, 24-hour heartburn relief*
- #1 DOCTOR and GASTROENTEROLOGIST RECOMMENDED frequent heartburn medicine for 15 straight years^ May be HSA and FSA eligible**
- OVER 30 MILLION AMERICANS have used Prilosec OTC Omeprazole 20mg pills as their frequent heartburn medicine
- SATISFACTION GUARANTEED or your money back
info:
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Specifications
Over-the-counter medicine type
Acid Reducer
Health concern
Acid Reflux
Active ingredients
Omeprazole
Medicine strength
20mg
Indications
Health Concern
Acid Reflux
Directions
Dosage
1
Instructions
Directions: For adults 18 years of age and older. This product is to be used once a day (every 24 hours), every day for 14 days. It may take 1 to 4 days for full effect; some people get complete relief of symptoms within 24 hours. 14-Day Course of Treatment: Swallow 1 tablet with glass of water before eating in the morning. Take every day for 14 days. Do not take more than 1 table a day. Do not use for more than 14 days unless directed by your doctor. Swallow whole. Do not chew or crush tablets. Repeated 14-Day Courses (if needed): You may repeat a 14-day course every 4 months. Do not take for more than every 4 months unless directed by a doctor. Tips for Managing Heartburn: Do not lie flat or bend over after eating. Do not wear tight-fitting clothing around the stomach. Do not eat before bedtime. Raise the head of your bed. Avoid heartburn-causing foods such as rich, spicy, fatty or fried foods, chocolate, caffeine, alcohol and certain fruits and vegetables. Eat slowly and avoid big meals. If overweight, lose weight. Quit smoking. Children Under 18 Years of Age: Ask a doctor. Heartburn in children may sometimes be caused by a serious condition.
Warranty
Warranty information
Please be aware that the warranty terms on items offered for sale by third party Marketplace sellers may differ from those displayed in this section (if any). To confirm warranty terms on an item offered for sale by a third party Marketplace seller, please use the 'Contact seller' feature on the third party Marketplace seller's information page and request the item's warranty terms prior to purchase.
Ingredients
Ingredients
Active Ingredient (in each tablet): Omeprazole Delayed-Release Tablet 20 mg (Equivalent to 20.6 mg Omeprazole Magnesium) (Acid Reducer)Inactive Ingredients: Glyceryl Monostearate, Hydroxypropyl Cellulose, Hypromellose, Iron Oxide, Magnesium Stearate, Methacrylic Acid Copolymer, Microcrystalline Cellulose, Paraffin, Polyethylene Glycol 6000, Polysorbate 80, Polyvinylpyrrolidone, Sodium Stearyl Fumarate, Starch, Sucrose, Talc, Titanium Dioxide, Triethyl Citrate
Active Ingredients
Omeprazole
Active Ingredient Name
Omeprazole
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Customer ratings & reviews
How item rating is calculated
Reviews summary
Pros
- : Relieves heartburn for 24 hours.
- : Offers lower cost compared to others.
- : Helps manage stomach acid production.
Generated by AI
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Showing 1-3 of 229 reviews
May 14, 2026
Kevin Jones
5 out of 5 stars review
Seller Verified Purchase
Prilosec
Works really good for acid reflux
Review from samsclub.com
Helpful?155JS8E8WCCM162543353
Jan 20, 2026
Mary
5 out of 5 stars review
Seller Verified Purchase
Quick Relief
It works quickly allowing me fast relief and moving on with my day.
Review from samsclub.com
Helpful?155JS8E8WCCM162543353
Jul 1, 2025
Imelda Bustamante
5 out of 5 stars review
Seller Verified Purchase
Sam's Reducing more than cost!!
Prilosec is a very effective and respected product, Sam's Club has it for a great price, and is always available.
Review from samsclub.com
Helpful?155JS8E8WCCM162543353
