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Life Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets
Key item features
- A reason to smile – S-Adenosyl-Methionine (SAMe) is made naturally by your body. It has a variety of well-studied benefits, including that supplementing with SAMe helps maintain a stable mood and healthy mental outlook.
- Comfortable joints – SAMe helps promote joint tissue health and function. SAMe levels decline over time, so getting this daily, high-quality SAMe supplement will help keep you comfortable from head to toe!
- Liver protection – S-Adenosyl-Methionine (SAMe) helps your body produce glutathione, a powerful antioxidant that helps protect liver cells from oxidizing free radical compounds.
- Ingredients matter – We use only pure, high-quality ingredients. The majority of our products are non-GMO and gluten-free—and a Certificate of Analysis is available for every one.
- Live your healthiest life - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. That’s why so many of our nutritional formulas are designed using specific ingredients and amounts based on scientific studies.
Specs
- BrandLife Extension
- Size60 Count (Pack of 1)
- Enteral medication formTablets
- Primary ingredientS-Adenosyl-Methionine
- Medicine strength400 mg
- Vitamin & supplement typeLiver Detox & Support, Mood Support
Current price is USD$49.50
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Columbus, 43215
Arrives by Thu, Feb 12
.Order within 13 hr 37 min
Sold by Life Extension Buyers Club|Pro Seller
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4.657360406091371 stars out of 5, based on 1183 seller reviews(4.7)1183 seller reviews
Free 90-day returns
About this item
Product details
SAMe (S-Adenosyl-Methionine) is a popular nutrient formula for mood health, joint health and liver health. This mood support supplement contains 400 mg of clinically studied S-Adenosyl-Methionine in every dose. SAMe benefits many metabolic functions in the body, from mood and joint health to healthy glutathione production. SAMe contains 60 enteric-coated vegetarian tablets, enough for a 20- to 60-day supply. Non-GMO.
- A reason to smile – S-Adenosyl-Methionine (SAMe) is made naturally by your body. It has a variety of well-studied benefits, including that supplementing with SAMe helps maintain a stable mood and healthy mental outlook.
- Comfortable joints – SAMe helps promote joint tissue health and function. SAMe levels decline over time, so getting this daily, high-quality SAMe supplement will help keep you comfortable from head to toe!
- Liver protection – S-Adenosyl-Methionine (SAMe) helps your body produce glutathione, a powerful antioxidant that helps protect liver cells from oxidizing free radical compounds.
- Ingredients matter – We use only pure, high-quality ingredients. The majority of our products are non-GMO and gluten-free—and a Certificate of Analysis is available for every one.
- Live your healthiest life - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. That’s why so many of our nutritional formulas are designed using specific ingredients and amounts based on scientific studies.
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Specifications
Brand
Life Extension
Size
60 Count (Pack of 1)
Enteral medication form
Tablets
Primary ingredient
S-Adenosyl-Methionine
Indications
Stop Use Indications
SAMe should not be taken by those diagnosed with bipolar disorder
Health Concern
Liver Detox & Support Mood Support
Directions
Dosage
FOR JOINT SUPPORT: Take one (1) tablet three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. FOR MOOD SUPPORT: Take one (1) tablet four times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid
Instructions
Read the entire label and follow the directions carefully prior to use. Store in a cool, dry place.
Warranty
Warranty information
Please be aware that the warranty terms on items offered for sale by third party Marketplace sellers may differ from those displayed in this section (if any). To confirm warranty terms on an item offered for sale by a third party Marketplace seller, please use the 'Contact seller' feature on the third party Marketplace seller's information page and request the item's warranty terms prior to purchase.
Ingredients
Ingredients
S-Adenosyl-Methionine 400 mg Other ingredients: cellulose, methacrylic acid copolymer, mannitol, citric acid, stearic acid, silica, hypromellose, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, calcium carbonate, yellow ochre. Non-GMO
Warnings
Warning Text
KEEP OUT OF REACH OF CHILDREN. DO NOT EXCEED RECOMMENDED DOSE. Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. To report a serious adverse event or obtain product information, contact 1-866-280-2852.
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| Size | 60 Count (Pack of 1)Life Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets | 0.2 lbsLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 Capsules | 30 TabletLife Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 Tablets | 60 Count (Pack of 1)Jarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs | 2.2 lb (35 oz)PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan Supplement | 400 CapsulesNutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement |
|---|---|---|---|---|---|---|
| Enteral medication form | TabletsLife Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets | CapsulesLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 Capsules | TabletsLife Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 Tablets | TabletsJarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs | -PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan Supplement | CapsulesNutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement |
| Primary ingredient | S-Adenosyl-MethionineLife Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets | D,L-phenylalanineLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 Capsules | L-TheanineLife Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 Tablets | SAMeJarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs | -PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan Supplement | TaurineNutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement |
| Medicine strength | 400 mgLife Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets | 500mgLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 Capsules | -Life Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 Tablets | -Jarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs | -PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan Supplement | -Nutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement |
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9784.3 out of 5 Stars. 978 reviewsSave withShipping, arrives in 2 days100+ bought since yesterday Qunol Magnesium Glycinate Tablets for Nerve, Bone, and Muscle Support, 300mg, 60 Count, Two Tablet Dose. $14.88 24.8 ¢/count
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11024.6 out of 5 Stars. 1102 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowNordic Naturals Ultimate Omega 2X Sport, 2150 Mg, Fish Oil, 60 Ct $47.56 79.3 ¢/count
$4756current price $47.5679.3 ¢/countNordic Naturals Ultimate Omega 2X Sport, 2150 Mg, Fish Oil, 60 Ct
55 out of 5 Stars. 5 reviewsShipping, arrives in 3+ daysBest seller Nature's Bounty Biotin Supplement, 10000mcg Hair Skin Nails Beauty Support, 180 Rapid Release Softgels $15.98 8.9 ¢/count
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Sponsored$1598current price $15.988.9 ¢/countNature's Bounty Biotin Supplement, 10000mcg Hair Skin Nails Beauty Support, 180 Rapid Release Softgels
3394.7 out of 5 Stars. 339 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrow100+ bought since yesterday Nature’s Bounty Biotin Supplement, 10000mcg, 120 Rapid Release Softgels $8.88
100+ bought since yesterday
Sponsored$888current price $8.88Nature’s Bounty Biotin Supplement, 10000mcg, 120 Rapid Release Softgels
14594.7 out of 5 Stars. 1459 reviewsSave withPickup tomorrowDelivery todayShipping, arrives tomorrowLife Extension Super Omega-3 EPA/DHA Fish Oil, Sesame Lignans & Olive Extract – Heart Health, Brain Health, Inflammation Health Support, Gluten-Free, Enteric-Coated, Non-GMO, 120 Softgels $26.33
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6394.7 out of 5 Stars. 639 reviewsSave withShipping, arrives in 2 daysNOW Supplements, Vitamin B-100, Energy Production*, Nervous System Health*, 100 Veg Capsules $13.02 Was $19.39
Now$1302current price Now $13.02, Was $19.39$19.39NOW Supplements, Vitamin B-100, Energy Production*, Nervous System Health*, 100 Veg Capsules
774.9 out of 5 Stars. 77 reviewsSave withShipping, arrives in 2 daysSerovital-hgh Anti-Aging Supplement Capsules, 120 Ct $85.99 Was $99.00
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Showing 1-3 of 89 reviews
Aug 31, 2025
SANDRA
5 out of 5 stars review
Seller Verified Purchase
Feel better with daily SAMe use.
A regular part of my daily supplements.
Review from Life Extension
Helpful?2TBU02S56C6O383698113
Nov 2, 2025
SANDY
5 out of 5 stars review
Seller Verified Purchase
No aching knees
If I don't get my Sam-e, my joints hurt (and it helps my attitude too!).
Review from Life Extension
Helpful?2TBU02S56C6O383698113
Apr 26, 2020
PAULA
5 out of 5 stars review
Seller Verified Purchase
Ahhhhh!
This in conjunction with my collagen enhancing drops in a little OJ is the best tonic for me twice a day. I have used SAMe over the last 10 years and I swear by it for an uplifting of my mood and for the general overall feeling of wellness [This review was collected as part of a promotion.]
Review from lifeextension.com
Helpful?2TBU02S56C6O383698113
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