Life Extension SAMe, S-Adenosyl-Methionine, 400 mg,  mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets
Life Extension SAMe, S-Adenosyl-Methionine, 400 mg,  mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets
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Life Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets

4.8 stars out of 99 reviews
(4.8)|
99 ratings

Key item features

  • A reason to smile – S-Adenosyl-Methionine (SAMe) is made naturally by your body. It has a variety of well-studied benefits, including that supplementing with SAMe helps maintain a stable mood and healthy mental outlook.
  • Comfortable joints – SAMe helps promote joint tissue health and function. SAMe levels decline over time, so getting this daily, high-quality SAMe supplement will help keep you comfortable from head to toe!
  • Liver protection – S-Adenosyl-Methionine (SAMe) helps your body produce glutathione, a powerful antioxidant that helps protect liver cells from oxidizing free radical compounds.
  • Ingredients matter – We use only pure, high-quality ingredients. The majority of our products are non-GMO and gluten-free—and a Certificate of Analysis is available for every one.
  • Live your healthiest life - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. That’s why so many of our nutritional formulas are designed using specific ingredients and amounts based on scientific studies.
Current price is $49.50
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Life Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets
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Comparison Chart:
Size60 Count (Pack of 1)Life Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets0.2 lbsLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 Capsules30 TabletLife Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 Tablets60 Count (Pack of 1)Jarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs2.2 lb (35 oz)PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan Supplement400 CapsulesNutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement
Enteral medication formTabletsLife Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tabletsCapsulesLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 CapsulesTabletsLife Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 TabletsTabletsJarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs-PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan SupplementCapsulesNutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement
Primary ingredientS-Adenosyl-MethionineLife Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tabletsD,L-phenylalanineLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 CapsulesL-TheanineLife Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 TabletsSAMeJarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs-PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan SupplementTaurineNutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement
Medicine strength400 mgLife Extension SAMe, S-Adenosyl-Methionine, 400 mg, mood health, liver health and joint support supplement, non-GMO, vegetarian, gluten free, 60 enteric-coated tablets500mgLife Extension D, L-Phenylalanine Capsules, 500 mg – Supports Mood Health, Promotes Neurotransmitter Health – Gluten-Free, Non-GMO, Vegetarian – 100 Capsules-Life Extension Theanine XR™ Stress Relief – L-Theanine – Promotes a Calm Response to Daytime Stress – Non-GMO, Gluten-Free, Vegetarian – 30 Tablets-Jarrow Formulas SAM-e, Promotes Joint Strength and Mood, 400 mg, 60 Enteric-Coated Tabs-PrimaForce L-Leucine Powder, 1 KG - Non-GMO, Gluten-Free, and Vegan Supplement-Nutricost Taurine 1000mg, 400 Capsules - Non-GMO & Gluten Free Supplement
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4.8 out of 5 stars
stars99 ratings89 reviews
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Showing 1-3 of 89 reviews

Aug 31, 2025
SANDRA
5 out of 5 stars review

Seller Verified Purchase

Feel better with daily SAMe use.

A regular part of my daily supplements.

Review from Life Extension
Helpful?2TBU02S56C6O383698113
Nov 2, 2025
SANDY
5 out of 5 stars review

Seller Verified Purchase

No aching knees

If I don't get my Sam-e, my joints hurt (and it helps my attitude too!).

Review from Life Extension
Helpful?2TBU02S56C6O383698113
Apr 26, 2020
PAULA
5 out of 5 stars review

Seller Verified Purchase

Ahhhhh!

This in conjunction with my collagen enhancing drops in a little OJ is the best tonic for me twice a day. I have used SAMe over the last 10 years and I swear by it for an uplifting of my mood and for the general overall feeling of wellness [This review was collected as part of a promotion.]

Review from lifeextension.com
Helpful?2TBU02S56C6O383698113