Khronicheskie zabolevaniya pecheni, assotsiirovannye s gepatotropnymi virusami, a takzhe zhelchnokamennaya bolezn' yavlyayutsya ser'eznoy sotsial'no-ekonomicheskoy i kliniko-epidemiologicheskoy problemoy zdravookhraneniya vsekh stran mira.Pri gepatobiliarnoy patologii markery endotelial'noy disfunktsii demonstriruyut vzaimosvyaz' s vyrazhennost'yu kliniko-biokhimicheskikh sindromov tsitoliza, kholestaza, pechenochno-kletochnoy nedostatochnosti, mezenkhimal'no-vospalitel'nym sindromom, narusheniyami trombotsitarnogo gemostaza, vyrazhennost'yu fibroza pecheni, nespetsificheskogo vospalitel'nogo otveta, psikhovegetativnogo sindroma i urovnem virusnoy nagruzki. Polimorfizm gena endotelial'noy sintazy oksida azota podtverzhdaet predraspolozhennost' k razvitiyu gepatobiliarnoy patologii. Markery funktsional'nogo sostoyaniya endoteliya obladayut vysokoy diagnosticheskoy, prognosticheskoy znachimost'yu i mogut primenyat'sya dlya differentsial'noy diagnostiki stepeni porazheniya pecheni, a takzhe otsenki effektivnosti terapii.
