Overall pick
Mucinex Nightshift Sinus Medicine, OTC Fever Reducer, Cough Suppressant, Nasal Decongestant, 6 fl oz
Key item features
- COUGH MEDICINE ADULTS: Tackle nighttime coughing woes head-on with Mucinex Nightshift Sinus; This liquid formula helps to relieve your worst nighttime sinus and nasal congestion symptoms, so you can wake up ready to conquer the day
- COLD MEDICINE: Find relief from fever, headache, minor aches, sore throat, cough, sneezing, and runny nose with Mucinex Nightshift Sinus—a powerful liquid formula designed to tackle nighttime sinus symptoms effectively
- NIGHTTIME COLD AND FLU SYMPTOM RELIEF: Mucinex Nightshift Sinus helps to reduce fever, relieve headache, minor aches and pains, sore throat, coughing, sneezing, runny nose for a better morning
- SINUS RELIEF + SORE THROAT RELIEF: Mucinex Nightshift is a powerful sinus medicine that provides sinus relief & sore throat relief; Contains Acetaminophen which helps reduce fever & relieves minor aches & pains including sore throat pain
- MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCl - Nasal Decongestant; Triprolidine HCl – Antihistamine
- USAGE: Use as directed; For ages 12+ years
- TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended Brand** so you can feel confident choosing Mucinex this cold & flu season
- FSA & HSA Eligible: Save Up to 30%; Cover out-of-pocket expenses with pre-tax dollars; Product eligibility may vary by plan; Check with your benefits administrator to determine which expenses are eligible before you shop
- *IQVIA using ProVoice Survey, August 2023; **U.S. News & World Report/Pharmacy Times 2023-2024
Specs
- Health concernCold, Sinus Relief
- Age groupAdult
- FormLiquid
- SymptomsCough
- Treatment effective time4 h
- Product net content parent6 Fluid Ounces
Reviews summary
Pros
- : Provides quick symptom alleviation.
- : Relieves congestion and coughing for restful sleep.
- : Enables restful sleep despite nasal congestion.
- : Relieves symptoms overnight for a better start.
- : Relieves nasal and throat congestion for restful sleep.
Neutral
- : Can be rich and fruity, but also bitter and overpowering.
Generated by AI
Current price is USDNow $12.48
You save $1.51
was $13.99$13.99
$2.08/fl ozYou save$1.51
Price when purchased online
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About this item
Product details
Experience relief from nighttime cold and sinus symptoms with Mucinex Nightshift Sinus, the trusted solution for adults seeking nighttime symptom relief from sinus discomfort. This liquid cold medicine is expertly formulated to address a range of cold and flu symptoms, including fever, headache, minor aches and pains, sore throat, cough, sneezing, and runny nose. Crafted with care to provide effective symptom relief, Mucinex Nightshift Sinus offers targeted support for those struggling with sinus congestion and associated discomfort, allowing you to breathe easier and help you get to sleep at night. Say goodbye to nighttime cold and flu symptoms such as coughing fits or nasal congestion, and wake up ready to tackle your day. Whether you're battling a common cold or sinus congestion, Mucinex Nightshift Sinus is your go-to solution for nighttime relief of cold and flu symptoms. Get the symptom relief you need so you can get the rest you need to recover fully. Don't let nighttime cold and sinus symptoms disrupt your sleep any longer. Trust Mucinex Nightshift Sinus to provide the nighttime symptom relief you need for a better morning. Try Mucinex Nightshift Sinus and experience the difference for yourself.
- COUGH MEDICINE ADULTS: Tackle nighttime coughing woes head-on with Mucinex Nightshift Sinus; This liquid formula helps to relieve your worst nighttime sinus and nasal congestion symptoms, so you can wake up ready to conquer the day
- COLD MEDICINE: Find relief from fever, headache, minor aches, sore throat, cough, sneezing, and runny nose with Mucinex Nightshift Sinus—a powerful liquid formula designed to tackle nighttime sinus symptoms effectively
- NIGHTTIME COLD AND FLU SYMPTOM RELIEF: Mucinex Nightshift Sinus helps to reduce fever, relieve headache, minor aches and pains, sore throat, coughing, sneezing, runny nose for a better morning
- SINUS RELIEF + SORE THROAT RELIEF: Mucinex Nightshift is a powerful sinus medicine that provides sinus relief & sore throat relief; Contains Acetaminophen which helps reduce fever & relieves minor aches & pains including sore throat pain
- MUCINEX NIGHTSHIFT SINUS ACTIVE INGREDIENTS: Contains Acetaminophen - Pain reliever and fever reducer; Dextromethorphan HBr - Cough suppressant; Phenylephrine HCl - Nasal Decongestant; Triprolidine HCl – Antihistamine
- USAGE: Use as directed; For ages 12+ years
- TRUSTED BRAND: Mucinex is the #1 Cough & Cold Brand Doctor's Trust* and is also the #1 Pharmacist Recommended Brand** so you can feel confident choosing Mucinex this cold & flu season
- FSA & HSA Eligible: Save Up to 30%; Cover out-of-pocket expenses with pre-tax dollars; Product eligibility may vary by plan; Check with your benefits administrator to determine which expenses are eligible before you shop
- *IQVIA using ProVoice Survey, August 2023; **U.S. News & World Report/Pharmacy Times 2023-2024
info:
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Specifications
Health concern
Cold, Sinus Relief
Age group
Adult
Form
Liquid
Symptoms
Cough
Indications
Stop Use Indications
Stop use and ask a doctor if nervousness, dizziness, or sleeplessness occur; pain, nasal congestion, or cough gets worse or lasts more than 7 days; fever gets worse or lasts more than 3 days; redness or swelling is present; new symptoms occur; cough comes back, or occurs with fever, rash, or headache that lasts. These could be signs of a serious condition.
If pregnant or breast-feeding, ask a health professional before use.
Health Concern
Cold Sinus Relief
Directions
Dosage
Do not take more than directed (see Overdose warning)Do not take more than 4 doses in any 24-hour periodMeasure only with dosing cup providedDo not use dosing cup with other productsDose as follows or as directed by a doctorAdults and children 12 years of age and older: 20 mL in dosing cup provided every 4 hoursChildren under 12 years of age: Do not use.
Instructions
Peel corner to read complete drug facts and information. Do not take more than directed (see Overdose Warning). Do not take more than 4 doses in any 24-hour period. Measure only with dosing cup provided. Do not use dosing cup with other products. Dose as follows or as directed by a doctor. Adults and Children 12 Years of Age and Older: 20 mL in dosing cup provided every 4 hours. Children Under 12 Years of Age: Do not use.
Ingredients
Inactive Ingredients
ammonium glycyrrhizate, anhydrous citric acid, ascorbic acid, edetate disodium, FD&C blue no. 1, FD&C red no. 40, flavors, glycerin (soy), propylene glycol, sodium benzoate, sorbitol, sucralose, triacetin, triethyl citrate, water, xanthan gum
Ingredients
ACTIVE INGREDIENTS; (in each 20 mL); MUCINEX Nightshift Sinus; Acetaminophen 650 mg Purpose(s) Pain reliever/fever reducer; Dextromethorphan HBr 20 mg Purpose(s) Cough suppressant; Phenylephrine HCl 10 mg Purpose(s) Nasal decongestant; Triprolidine HCl 2.5 mg Purpose(s) Antihistamine
Active Ingredients
Acetaminophen Dextromethorphan HBr Phenylephrine HCl Triprolidine HCl
Active Ingredient Name
In Each 20 mL: Active Ingredients: Acetaminophen (650 mg), Pain Reliever/Fever Reducer; Dextromethorphan HBR (20 mg), Cough Suppressant; Triprolidine HCI (2.5 mg), Antihistamine; Triprolidine HCI (2.5 mg), Antihistamine. Inactive Ingredients: Ammonium Glycyrrhizate, Anhydrous Citric Acid, Ascorbic Acid, Edetate Disodium, FD&C Blue No. 1, FD&C Red No. 40, Flavors, Glycerin (Soy), Propylene Glycol, Sodium Benzoate, Sorbitol, Sucralose, Triacetin, Triethyl Citrate, Water, Xanthan Gum.
Warnings
State Chemical Disclosure
None
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Customer ratings & reviews
How item rating is calculated
Reviews summary
Pros
- : Provides quick symptom alleviation.
- : Relieves congestion and coughing for restful sleep.
- : Enables restful sleep despite nasal congestion.
- : Relieves symptoms overnight for a better start.
- : Relieves nasal and throat congestion for restful sleep.
Neutral
- : Can be rich and fruity, but also bitter and overpowering.
Generated by AI
Customer photos
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Showing 1-3 of 174 reviews
Jan 7, 2026
Pamela
5 out of 5 stars review
Verified Purchase
A good night sleep, and sinus pressure gone!
I got a good nights sleep, and this product relieved my sinus congestion and headache. I woke up the next day feeling so much better. I told my sister about this product, and she said it worked great for her as well.
Helpful?4731K64W9DY1492872539
Jul 28, 2025
Walmart customer
Top Reviewer
5 out of 5 stars review
Verified Purchase
You can breathe and runny nose.
I am allergic to many things outside and inside of home. I take 2 allergy medicine twice a day. I have sinus problems everyday. Had sinusitis and could not stay stocked kleenex. Discovered Mucinex Dayshift/Nightshift. They come package of 2. They are also often sold out.
Helpful?4731K64W9DY1492872539
Aug 27, 2025
Sandra
5 out of 5 stars review
Verified Purchase
mucinex nightshift sinus Max liquid works very well. problem is, the price keeps going UP until people can't afford it. PRICE NEEDS TO COME DOWN... TO NO MORE THAN $10 per bottle.
Helpful?4731K64W9DY1492872539
