Equate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients

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Equate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients

Name: Equate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients
Brand: Equate
SKU: 21644823
Price: 9.97 USD
Availability: InStock
Rating: 4.7 (1875 reviews)

4.7 stars out of 1875 reviews

(4.7)|

1,875 ratings

Equate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients Equate Nighttime Cold and Flu Relief Liquid Original Flavor 24 fl oz 2 Count

Multipack Quantity:1

Key item features

Active Ingredients: Compare to NyQuil Cold and Flu active ingredients: Acetaminophen (pain reliever and fever reducer), Dextromethorphan HBr (cough suppressant), and Doxylamine Succinate (antihistamine)
Maximum Strength: Equate Nighttime Cold and Flu Relief provides maximum strength, multi-symptom relief to help you sleep
Powerful Nighttime Relief: Each dose relieves minor aches and pains, fever, sore throat, sneezing, runny nose and cough for up to 6 hours so you can rest
Liquid Medicine: Equate Nighttime Cold and Flu Relief is a liquid medicine in original flavor; get the relief you need in a liquid
Ages 12 and Over: This cold and flu medicine is safe for adults and children ages 12 and over; gluten free

Specs

Over-the-counter medicine type
Pain Relief, Fever Reducer, Cough & Cold, Flu Relief, Acetaminophen, Antihistamines
Health concern
Cold, Flu, Body Aches & Pains
Brand
Equate
Age group
Adult
Form
Liquid
Flavor
Original

Reviews summary

Pros

: Helps promote restful night's sleep.
: Costs less than similar products.
: Relieves cold and flu symptoms quickly.
: Works similarly to nyquil at a lower price point.

Cons

: May be too intense for some users' preferences.

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Current price is Now $9.97

You save $3.01

was $12.98

41.5 ¢/fl oz

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About this item

Product details

Compare to NyQuil Cold and Flu active ingredients. Calm your cold and flu symptoms so you can get the rest you need. Equate Nighttime Cold and Flu provides powerful relief for your minor aches and pains, fever, sore throat, sneezing, runny nose and cough. Each dose combines Acetaminophen (pain reliever/fever reducer), Dextromethorphan HBr (cough suppressant) and Doxylamine Succinate (antihistamine) with ten percent alcohol to give you maximum strength, multi-symptom relief. This cold and flu liquid medicine in original flavor helps relieve major flu symptoms for up to 6 hours so you can rest. Dosage cup included. For ages 12 and over. This product does not contain gluten.

Active Ingredients: Compare to NyQuil Cold and Flu active ingredients: Acetaminophen (pain reliever and fever reducer), Dextromethorphan HBr (cough suppressant), and Doxylamine Succinate (antihistamine)
Maximum Strength: Equate Nighttime Cold and Flu Relief provides maximum strength, multi-symptom relief to help you sleep
Powerful Nighttime Relief: Each dose relieves minor aches and pains, fever, sore throat, sneezing, runny nose and cough for up to 6 hours so you can rest
Liquid Medicine: Equate Nighttime Cold and Flu Relief is a liquid medicine in original flavor; get the relief you need in a liquid
Ages 12 and Over: This cold and flu medicine is safe for adults and children ages 12 and over; gluten free

info:

We aim to show you accurate product information. Manufacturers, suppliers and others provide what you see here, and we have not verified it.

Specifications

Over-the-counter medicine type

Pain Relief, Fever Reducer, Cough & Cold, Flu Relief, Acetaminophen, Antihistamines

Health concern

Cold, Flu, Body Aches & Pains

Active ingredients

Acetaminophen 650mg, Dextromethorphan HBr 30mg, Doxylamine succinate 12.5mg

Medicine strength

Acetaminophen 650 mg, Dextromethorphan HBr 30 mg, Doxylamine succinate 12.5 mg

Indications

Stop Use Indications

Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take: more than 4,000 mg of acetaminophen in 24 hours; with other drugs containing acetaminophen; 3 or more alcoholic drinks every day while using this product. Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include: skin reddening; blisters; rash. If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly. Do not use: with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist; if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product; if you have ever had an allergic reaction to this product or any of its ingredients. Ask a doctor before use if you have: liver disease; glaucoma; cough that occurs with too much phlegm (mucus); a breathing problem such as emphysema or chronic bronchitis; trouble urinating due to an enlarged prostate gland; persistent or chronic cough as occurs with smoking, asthma, or emphysema; a sodium-restricted diet. Ask a doctor or pharmacist before use if you are: taking sedatives or tranquilizers; taking the blood thinning drug warfarin. When using this product: excitability may occur, especially in children; marked drowsiness may occur; avoid alcoholic drinks; be careful when driving a motor vehicle or operating machinery; alcohol, sedatives, and tranquilizers may increase drowsiness. Stop use and ask a doctor if: pain or cough gets worse or lasts more than 7 days; fever gets worse or lasts more than 3 days; redness or swelling is present; new symptoms occur; cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition. If pregnant or breast-feeding, ask a health professional before use. Keep out of reach of children. Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away (1-800-222-1222). Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Health Concern

Cold Flu Body Aches & Pains

Directions

Dosage

Do not take more than directed (see Overdose warning). Do not take more than 4 doses in any 24-hour period. Measure only with dosing cup provided. Do not use any other dosing device. mL = milliliter. Keep dosing cup with product. Adults and children 12 years and over: 30 mL every 6 hours. Children under 12 years of age: do not use. When using other Daytime or Nighttime products, carefully read each label to ensure correct dosing.

Instructions

Warranty

Warranty information

Ingredients

Inactive Ingredients

Inactive ingredients: acesulfame potassium, alcohol, citric acid, D&C yellow #10, FD&C green #3, FD&C yellow #6, flavor, high fructose corn syrup, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sodium citrate. Each 30 mL contains: potassium 5 mg and sodium 19 mg.

Ingredients

Active Ingredients (in each 30 mL): Acetaminophen 650 mg, Dextromethorphan HBr 30 mg, Doxylamine Succinate 12.5 mg. Inactive ingredients: acesulfame potassium, alcohol, citric acid, D&C yellow #10, FD&C green #3, FD&C yellow #6, flavor, high fructose corn syrup, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sodium citrate. Each 30 mL contains: potassium 5 mg and sodium 19 mg.

Active Ingredients

Acetaminophen 650mg Dextromethorphan HBr 30mg Doxylamine succinate 12.5mg

Active Ingredient Name

Acetaminophen Dextromethorphan HBr Doxylamine succinate

Compare with similar items

Comparison Overview:
Product	Viewing this item Equate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients current price Now $9.97, Was $12.98 Equate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients 4.7 out of 5 Stars. 1875 reviews	Equate Nighttime Cold & Flu Liquid, 6 fl oz, Compare to Mucinex® Nightshift® Cold & Flu Active Ingredients current price $5.47 Equate Nighttime Cold & Flu Liquid, 6 fl oz, Compare to Mucinex® Nightshift® Cold & Flu Active Ingredients 4.6 out of 5 Stars. 105 reviews	Equate Daytime Cold and Flu Relief, Non-Drowsy, Multi-Symptom Medicine for Cough, 12 fl oz current price Now $5.47, Was $6.98 Equate Daytime Cold and Flu Relief, Non-Drowsy, Multi-Symptom Medicine for Cough, 12 fl oz 4.7 out of 5 Stars. 1637 reviews

Comparison Chart:
Over-the-counter medicine type	Pain ReliefEquate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients	Cough & ColdEquate Nighttime Cold & Flu Liquid, 6 fl oz, Compare to Mucinex® Nightshift® Cold & Flu Active Ingredients	Cough & ColdEquate Daytime Cold and Flu Relief, Non-Drowsy, Multi-Symptom Medicine for Cough, 12 fl oz
Health concern	ColdEquate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients	ColdEquate Nighttime Cold & Flu Liquid, 6 fl oz, Compare to Mucinex® Nightshift® Cold & Flu Active Ingredients	ColdEquate Daytime Cold and Flu Relief, Non-Drowsy, Multi-Symptom Medicine for Cough, 12 fl oz
Age group	AdultEquate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients	AdultEquate Nighttime Cold & Flu Liquid, 6 fl oz, Compare to Mucinex® Nightshift® Cold & Flu Active Ingredients	AdultEquate Daytime Cold and Flu Relief, Non-Drowsy, Multi-Symptom Medicine for Cough, 12 fl oz
Form	LiquidEquate Nighttime Cold and Flu Relief Liquid, Original Flavor, 24 fl oz (2x12 fl oz), Compare to Vicks® Nyquil® Cold & Flu Active Ingredients	LiquidEquate Nighttime Cold & Flu Liquid, 6 fl oz, Compare to Mucinex® Nightshift® Cold & Flu Active Ingredients	LiquidEquate Daytime Cold and Flu Relief, Non-Drowsy, Multi-Symptom Medicine for Cough, 12 fl oz

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Customer ratings & reviews

4.7 out of 5 stars

stars1,875 ratings368 reviews

How item rating is calculated

Reviews summary

Pros

: Helps promote restful night's sleep.
: Costs less than similar products.
: Relieves cold and flu symptoms quickly.
: Works similarly to nyquil at a lower price point.

Cons

: May be too intense for some users' preferences.

Generated by AI

Filtered and sorted results would be available on the new 'Customer ratings & reviews' page.

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Showing 1-3 of 368 reviews

Jan 12, 2026

charles

Item details

Multipack quantity: 1

5 out of 5 stars review

Verified Purchase

Works

There is no reason that a signature should be required for delivery! I might could understand why if I ordered a pallet full, but just two bottles makes no sense what so ever!

Helpful?

Feb 4, 2026

Moirabeth

Item details

Multipack quantity: 1

5 out of 5 stars review

Verified Purchase

Great relief

Does not have a horrible taste like other. I mean, it's still medicine tasting. but doesn't turn my stomach. It works great! I could feel relief within 10-15 minutes.

Helpful?

May 24, 2025

MaryK

Item details

Multipack quantity: 1

5 out of 5 stars review

Verified Purchase

Relief-in-a-bottle!

When you feel awful-- especially with a cold-- Equate Nighttime Cold and Flu Liquid is no less than heaven-sent! Just like Nyquil, but it costs far less, this liquid relief-in-a-bottle covers all those awful symptoms that make you feel so terrible. This has been especially wonderful because my husband has been hit with spring allergies with a cold on top. He's finally gotten some relief and some sleep. (Yay!)

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