This book contains the contributions presented at the 12th international KES conference on Smart Education and e-Learning (SEEL 2025). This book is being held on June 25-27, 2025, in Solin, Croatia, in both in-person and online modes. This book contains high-quality peer-reviewed papers that are grouped into several interconnected parts: Part 1--Smart Education, Part 2--Smart e-Learning, Part 3--Smart University, Part 4--Smart Education: Case Studies and Research, and Part 5--Smart Company: Case Studies and Research. This book serves as a useful source of research data and valuable information on current research projects, best practices, and case studies for faculty, scholars, Ph.D. students, administrators, and practitioners--all those who are interested in smart education, smart e-learning, smart university, and smart business/company paradigms, concepts, systems, and technology.