This book provides a comprehensive overview of oncocytic (
Hürthle cell) lesions, whether neoplastic or non-neoplastic, with a view to clarifying some uncertainties and helping clinicians reach an accurate diagnosis and choose the best therapeutic options.
Many recent studies have highlighted important facts relevant to oncocytic (
Hürthle cell) lesions and have proposed several clinical and non-clinical tools that may help in diagnosis and management. Recent molecular studies have shed light on the distinct oncogenic features of oncocytic/
Hürthle cell carcinomas, suggesting that they represent a separate pathological entity from both oncocytic/
Hürthle cell adenomas and follicular cell carcinomas. However, only a few facts are established, while challenges and debates still encompass most of the spectrum of oncocytic (
Hürthle cell) lesions.
The volume discusses a wide range of topics, including controversies
in nomenclature, origin, and cytology/histology of oncocytic (
Hürthle) cells, as well as controversies
in oncocytic cell lesion pathogenesis, biological and clinical behavior, diagnosis, and management.
Regarding oncocytic (
Hürthle cell) neoplasms, this book discusses controversies
in pathological classification, clinical presentation, diagnostic work-up, and therapeutic strategies. A special chapter addresses updates in genetic and molecular diagnostics of oncocytic (
Hürthle cell) carcinoma.
Finally, this book includes a chapter summarizing the recent international guidelines and recommendations related to oncocytic lesions, particularly carcinoma, thus aiding in decision-making and appropriate management.
This book is meant for all specialists entrusted with the care of patients suffering from oncocytic thyroid lesions: head and neck surgeons, maxillofacial surgeons, endocrine surgeons, endocrinologists, oncologists, and otolaryngologists.
