Hero image 0 of Life Extension High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets, 0 of 10
Life Extension High Potency Optimized Folate – L-methylfolate – Folic Acid, 8500 mcg DFE – Heart & Brain Support, Healthy Homocysteine Levels – Gluten-Free, Non-GMO, Vegetarian – 30 Tablets
Key item features
- High potency – This powerful folate supplement contains 8500 mcg of 5-MTHF folate, the bioactive form of folic acid. Choosing 5-MTHF instead of regular folic acid is a good option because not everyone can convert folate to 5-MTHF.
- Cardiovascular support – Folate is a heart-healthy B vitamin. Why? Folate helps maintain normal levels of homocysteine, a metabolic byproduct. Keeping homocysteine levels within normal range is an important biomarker for cardiovascular health.
- Cognitive health – Folate is also a “big brain” vitamin: it helps maintain cognitive health. Again, this has to do with keeping homocysteine levels within normal range, as homocysteine has also been associated with normal cognitive decline.
- Ingredients matter – We use only pure, high-quality ingredients. The majority of our products are non-GMO and gluten-free—and a Certificate of Analysis is available for every one.
- Live your healthiest life - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. That’s why so many of our nutritional formulas are designed using specific ingredients and amounts based on scientific studies.
Specs
- Vitamin & supplement typeFolate
- Primary ingredientFolate
- Health concernHeart Health
- Serv per cont30
- Serving size1
- Enteral medication & supplement formTablets
Current price is USD$13.50$22.50/ea
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About this item
Product details
Since not everyone has enough of the necessary enzymatic activity necessary to convert folic acid to 5-MTHF (the active form of folate), this highly potent dose of 5-MTHF makes it easier for you to get all the health benefits of the B vitamin folate. Indeed, you get 8500 mcg of dietary folate equivalents in every tablet. High Potency Optimized Folate helps maintain already normal levels of homocysteine, an important marker of heart health, and is also good for your brain health—specifically, maintaining healthy cognition. This heart and brain health supplement is also gluten-free, non-GMO and vegetarian.
- High potency – This powerful folate supplement contains 8500 mcg of 5-MTHF folate, the bioactive form of folic acid. Choosing 5-MTHF instead of regular folic acid is a good option because not everyone can convert folate to 5-MTHF.
- Cardiovascular support – Folate is a heart-healthy B vitamin. Why? Folate helps maintain normal levels of homocysteine, a metabolic byproduct. Keeping homocysteine levels within normal range is an important biomarker for cardiovascular health.
- Cognitive health – Folate is also a “big brain” vitamin: it helps maintain cognitive health. Again, this has to do with keeping homocysteine levels within normal range, as homocysteine has also been associated with normal cognitive decline.
- Ingredients matter – We use only pure, high-quality ingredients. The majority of our products are non-GMO and gluten-free—and a Certificate of Analysis is available for every one.
- Live your healthiest life - For over 40 years, we’ve been developing advanced, effective formulas made with the highest standards and based on the latest scientific findings. We believe the answers to a healthier, richer life are within reach, and that rigorous scientific research is the path to get us there. That’s why so many of our nutritional formulas are designed using specific ingredients and amounts based on scientific studies.
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Specifications
Brand
Life Extension
Size
8,500 mcg DFE 30 VEG TABS
Enteral medication & supplement form
Tablets
Primary ingredient
Folate
Indications
Stop Use Indications
CAUTION: Consult your healthcare provider if you are at risk of vitamin B12 deficiency, as high-dose folate may mask signs.
Health Concern
Heart Health
Directions
Dosage
Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.
Instructions
Read the entire label and follow the directions carefully prior to use. Store tightly closed in a cool, dry place.
Warranty
Warranty information
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Ingredients
Inactive Ingredients
Microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.
Ingredients
Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt] 8500 mcg° Other ingredients: microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate. °DFE (dietary folate equivalents) Non-GMO
Active Ingredients
Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt] 8500 mcg°
Active Ingredient Name
Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt], Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt]
Warnings
Warning Text
KEEP OUT OF REACH OF CHILDREN. DO NOT EXCEED RECOMMENDED DOSE. Do not purchase if outer seal is broken or damaged. When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating. To report a serious adverse event or obtain product information, contact 1-866-280-2852.
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Showing 1-3 of 140 reviews
Jan 18, 2020
Lydia
5 out of 5 stars review
Seller Verified Purchase
Important part of my health focus
As a women of 72 yrs, I am focused on every element of my health, and had issues that indicated a need for folate. Only trust Life Extension quality and their scientific info. [This review was collected as part of a promotion.]
Review from lifeextension.com
Helpful?44LOBSAH8DK0105396836
Jan 9, 2025
Mike
5 out of 5 stars review
Seller Verified Purchase
Doctor Recomended
My Doctor recommended this after my blood test showed low iron and a genetic malformation that doesn't allow my body to process regular iron supplements. After taking it less than a month my iron numbers nearly doubled. This will be something I take daily for the rest of my life.
Review from Life Extension
Helpful?44LOBSAH8DK0105396836
Jul 29, 2025
KULIE
5 out of 5 stars review
Seller Verified Purchase
This helps calm my busy mind at night
I learned this trick from Dr. Paul Saladino to take L-Methylfolate at night if you have genetic variants in the MTHFR and COMT. I often have issues with "wide awake" brain at bedtime as I'm not good at breaking down catecholamines including dopamine. This has been helping me sleep better immensely!!
Review from Life Extension
Helpful?44LOBSAH8DK0105396836
