I have been using SAM-e for about 4 months, I can say that I definitely see a difference in my mood.
As single woman taking care my bed ridden father for a about a year now (he had a severe stroke), I definitely had some trouble with depression and lethargic times. My brother and his wife had tried and said it was working well for them--so I decided to try it.
The first three days, I honestly could not tell a difference but after that it got more and more effective. I think it has helped keep my mood much more level and seem not be through continuous cycles of worry when I sleep. As a result, I sleep better and have more energy. (Obviously, there have been some days which I had real reasons to be upset-and the supplement does not change that, but a depressed state does not seem to be lingering in me like before).
Just FYI, I noticed if I stop or miss day and start up again it takes full day before I feel the effect again. I also found it works better if I take it right before I sleep.
Overall, I think SAM-e certainly not a cure all, but I definitely have NOT had nearly as many down days since I started taking it. It is a bit expensive, but worth it to me.
**It also supports joint health--I have noticed less back pain since starting this supplement.
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