First off, this box spring arrives in a package that's not overly heavy but is still large/unwieldy enough to require two people to lift it. However, because it's not heavy, as long as you have two people you'll be able to move it really easily.
Secondly, you can't help but worry about setting up things like this - whether you'll have the right tools, whether all the little pieces arrived intact, etc. No worries about that with this, because it is the simplest thing in the world to assemble. It arrives flat, folded in half, and doesn't really look like a box spring. My mom panicked and thought they had mistakenly sent us a bed frame, but I figured I'd follow the directions and see what happened. You put it on the floor. You unfold it. It literally springs into shape. You put it onto your bed frame, with the side labeled "TOP" facing upward.
All told, it took us less than 5 minutes to bring it upstairs, "assemble" it, and put it in place. I'm now typing this from the comfort of my newly box-spring'd bed, and I must say it's working out quite nicely so far. :)