These headphones are awesome. Right out of the box, getting connected and listening to music is seamless. I recommend downloading the app as it has steps to get you connected as well as equalizer settings and toggles for noise canceling as well as other features, but I will stress, it's not required for use.
Getting used to where the buttons are doesn't take long. They stick out enough and are different enough you can feel your way around. The play/pause, next and precious button slider combo is intuitive and easy to use. Holding the button in also invokes Siri if that's something you like to use. Volume up and down buttons are tactile and the noise canceling button can be used to toggle the feature on or off while holding it will turn on an auto-noise-sensing mode to monitor ambient noise and cancel sound based on your environment.
As far as comfort and fit, I don't have a problem wearing these for several hours. They fit my head nicely and don't fatigue my ears after extended use. My only gripe would be they don't hang around the neck comfortably. If you need to remove them to talk or have a chat, it's easier to just move one behind an ear. I would have liked to have seen a folding design or at least a hard case to put them in for travel or dropping in a gym bag.
Finally the sound. For me, personally, I'm not some huge audio nut who breaks down every pitch and note and criticizes it. It sounds great. The surround sound is very nice for movies, music sounds fantastic, and if you like some bass (I do), it has that too.
If you're looking for a great pair of headphones with all day battery, minimum ear fatigue, and sound you can be happy with, these should be in your cart!