I bought a pair of these New Balance 990v4's and was so enthralled by the way they fit, that I immediately bought another pair! The 10.5 part of the equation was right on, and the 6E part was heavenly. I've been a runner since the 1970's and always had a wide foot. I suppose as you get older your foot spreads a bit, mine from 4E to 6E. Conventional stores only carry 4E.
I will vouch for the workmanship that went into this shoe. New Balance has always been the "Cadillac" of running shoes, around the crowd I run with. With this pair there was no break in period. They just fit right from the start.
It was worth the extra money, although I got a pretty substantial discount from shoes.com. When your shoes don't fit, your day is ruined right there. Don't hesitate on these. Especially if you have feet like a duck like I do.