Tuberculosis: Diagnosis and Treatment

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Tuberculosis: Diagnosis and Treatment

Format:  Hardcover,

270 pages

Publisher: Stylus Pub Llc

Publish Date: May 2013

ISBN-13: 9781845938079

ISBN-10: 1845938070

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Book Information

The following content was provided by the publisher.
Tuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.

Specifications

Editor:
Publisher: Stylus Pub Llc
Publish Date: May 2013
ISBN-13: 9781845938079
ISBN-10: 1845938070
Format: Hardcover
Number of Pages: 270
Shipping Weight (in pounds): 1.65
Walmart No.: 9781845938079

Chapter outline

Diagnosis
Improving on microscopy in resource poor settings
The role of molecular tools in diagnosis of tuberculosis
Improving on the LJ slope - automated liquid culture
Phenotypic methods for antibiotic susceptibility testing
Interferon gamma assays in diagnosis and contact tracing
Measuring Immunological responses in the lung - the correct target?
Genotypic measures of antibiotic susceptibility
Sniffing out TB
Biomarkers for monitoring therapy
Lipid bodies and fas1 expression
Measuring gene expression by qPCR
Transcriptomic approaches to mapping responses to drug therapy
Modelling of responses to treatment
Monitoring therapy by bacterial load
Treatment
The new drugs pipeline
Clinical Trails for tuberculosis treatment - the challenge
SQ109 - clinical evaluation of a new drug
Rifamicins re-visited
QAB - a new paradigm for a new drug?

Book description

Tuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.

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