Safe-guard (fenbendazole) paste 10% is indicated for the control oflarge strongyles (strongylus edentatus, S. equinus, s vulgaris),encysted early third stage (hypobiotic), late third stage And fourthstage cyathostome larvae, small strongyles, pinworms (oxyuris equi),ascarids (parascaris equorum), And arteritis caused by fourth stagelarvae Of stronglus vulgaris in horses. Safe-guard (fenbendazole) paste10% is approved for use concomitantly with an approved form oftrichlorfon is approved for the treatment Of stomach bots (gasterophilusspp.) in horses. Refer To the manufacturer's label for directions foruse And cautions for trichlorfon.

Side effects associated with safe-guard (fenbendazole) paste 10% couldnot be established in well-controlled safety studies in horses withsingle doses as high as 454 mg/lb (1,000 mg/kg) And 15 consecutive dailydoses Of 22.7 mg/lb (50 mg/kg) particularly with higher doses, thelethal action Of fenbendazole may cause the release Of antigens by thedying parasites. This phenomenon may result in either a local orsystemic hypersensitive reaction. As with any drug, these reactionsshould be treated symptomatically. Safe-guard (fenbendazole) paste 10%has been evaluated for safety in pregnant mares during all stages ofgestation with doses as high as 11.4 mg/lb (25 mg/kg). No adverseeffects on reproductivity were detected. The recommended dose forcontrol Of 4th stage larvae Of strongylus vulgaris, 4.6 mg/lb (10mg/kg)daily for 5 consecutive days, has not been evaluated for safety installions or pregnant mares. Internal parasites: regular deworming atintervals Of six To eight weeks may be required due To the possibilityof reinfection. Migrating tissue parasites: in the case Of 4th stagelarvae Of strongylus vulgaris, treatment And retreatment should be basedon the life cycle And the epidemiology. Treatment should be initiated inthe spring And repeated in the fall after a six month interval. Optimumdeworming program for control Of S. vulgaris: optimum reduction Of S.vulgaris infections is achieved by reducing the infectivity Of thepastures. When horses are running on pasture, in temperate northamerica, maximum pasture infectivity occurs in october-december. Ifhorses are removed From those pastures in january , pasture infectivitywill decline To zero by july Q. egg production Of S. vulgaris is minimalfrom january through april, peaking in august And declining To minimalvalues in december. Recommended deworming program: december 1, february1, april 1, june 1, august 1, october 1. the two treatments that are inbold type are the recommended