Emerging Trends in Antibacterial Discovery: Answering the Call to Arms

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Emerging Trends in Antibacterial Discovery: Answering the Call to Arms

Format:  Hardcover,

460 pages

Publisher: Intl Specialized Book Services

Publish Date: Jul 2011

ISBN-13: 9781904455899

ISBN-10: 1904455891

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As bacterial antibiotic resistance continues to exhaust the supply of effective antibiotics, a global public health disaster appears likely. Poor financial investment in antibiotic research has exacerbated the situation. A call to arms - raised by several prestigious scientific organizations a few years ago - rallied the scientific community and now the scope of antibacterial research has broadened considerably. Multi-disciplinary approaches have yielded a wealth of new data on areas ranging from the identification of novel antibacterial targets to the use of biological agents for antibacterial therapy. In this book, respected international experts summarize the most important concepts and pioneering strategies currently being used to develop novel antibacterials. The book opens with chapters on cellular processes that could be used as novel antibacterial targets. Examples include cell division, efflux pumps, metabolite-sensing riboswitches, and bacterial secretion systems. These are followed by excellent chapters on the identification of new, naturally occurring antibacterial agents, including phage and biosynthetically engineered compounds. Understanding the host-microbe interaction and microbial communities and how they can be exploited to develop new antibacterial strategies is discussed in subsequent chapters. Other topics include antibacterial vaccines adjuvants, host defense peptides, antibodies, within-host models, and diagnostics.


Publisher: Intl Specialized Book Services
Publish Date: Jul 2011
ISBN-13: 9781904455899
ISBN-10: 1904455891
Format: Hardcover
Number of Pages: 460
Shipping Weight (in pounds): 2.95
Product in Inches (L x W x H): 7.0 x 9.75 x 1.0

Chapter outline

List of Contributorsp. v
Answering the Call to Armsp. 1
Answering the Call to Arms: Introduction and Overviewp. 3
Renewing Investment in Antibacterial Researchp. 21
Novel Targets and Sourcesp. 33
Mining Bacterial Cell Division for New Antibacterial Drugsp. 35
Efflux Pumps from Gram-negative Bacteria: From Structure and Function to Inhibitionp. 77
Metabolite-sensing Riboswitches as Antibacterial Drug Targetsp. 107
Targeting Bacterial Secretion Systems for the Development of Novel Therapeutic Agentsp. 131
Recent Developments in Natural Products: Potential Impact on Antibacterial Drug Discoveryp. 149
Biosynthetic Engineering of Antibacterial Natural Productsp. 171
Microbial Communities and Interactions with the Hostp. 193
Bacterial Phenotypes Refractory to Antibiotic-mediated Killing: Mechanisms and Mitigationp. 195
Quorum-sensing Inhibitors Disable Bacterial Biofilmsp. 211
The Indigenous Human Microbiotap. 225
Prospects for the Development of New Anti-TB Drugs Based on Novel Targets Related to the Host-Parasite Relationship in Tuberculosisp. 241
Biological Agents for Antibacterial Therapyp. 281
Current Strategies for Antibacterial Vaccine Developmentp. 283
Recent Advances in Vaccine Adjuvantsp. 303
Host Defence Peptidesp. 323
Antibodies for Antibacterialsp. 345
Therapeutic Applications of Phage Biology: History, Practice and Recommendationsp. 367
Enabling Antibacterial Discoveryp. 411
Role of Within-host Models in Target Identification, Compound Optimization and Dose Selectionp. 413
Advances and Applications in Diagnostic Microbiology and Antibacterial Discoveryp. 429
Changing the Therapeutic Paradigm in Antibacterial Drug Therapy and Discoveryp. 451

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