American Trypanosomiasis: Chagas Disease One Hundred Years of Research

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American Trypanosomiasis: Chagas Disease One Hundred Years of Research

Format:  Hardcover,

870 pages

Publisher: Elsevier

Publish Date: Sep 2010

ISBN-13: 9780123848765

ISBN-10: 0123848768

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The following content was provided by the publisher.

Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. This book provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: The host: human and mammalian reservoirsThe insect vectors: domestic and sylvatic vectorsThe causative parasite: "Trypanosoma cruzi"
* Informs and updates on all the latest developments in the field
* Contributions from leading authorities and industry experts

Specifications

Editor:
Editor:
Editor:
Publisher: Elsevier
Publish Date: Sep 2010
ISBN-13: 9780123848765
ISBN-10: 0123848768
Format: Hardcover
Number of Pages: 870
Shipping Weight (in pounds): 2.92
Product in Inches (L x W x H): 6.0 x 1.81 x 9.0

Chapter outline

General Aspects
History of the discovery of the American Trypanosomiasis (Chagas disease)
Chagas disease in pre-Colombian civilizations
Social and Medical aspects: morbidity and mortality in the general population
Current trends and future prospects for control of Chagas disease
Geographical distribution of Chagas disease
Insect Vectors
Classification and Phylogeny of the Triatominae
Biology of Triatominae
Population Genetics of Triatomines
Geographical distribution of Triatominae vectors in America
Control strategies against Triatominae
Non-Human Mammalian Hosts
Domestic and wild mammalian reservoirs
Veterinary aspects and experimental studies
The Causative Agent: Trypanosoma Cruzi
Classification and phylogeny of Trypanosoma cruzi
Biology of Trypanosoma cruzi and biological diversity
Biochemistry of Trypanosoma cruzi
Ultrastructure of Trypanosoma cruzi and its Interaction with Host Cells
Genetics of Trypanosoma cruzi
Sub-chapter: Nuclear genome
Sub-chapter: Kinetoplast genome
Experimental and Natural recombination in Trypanosoma cruzi
Reticulate Evolution in Trypanosoma cruzi: medical and epidemiological implications
Implications of Trypanosoma cruzi intraspecific diversity in the pathogenesis of Chagas Disease
Modes of Transmission
Vector transmission
Maternal-fetal transmission of Trypanosoma cruzi
Other forms of transmission
Immunology: Host-Parasite Interaction
Protective host response to parasite and its limitations
Pathological consequences of host response to parasite
Human genetic susceptibility to Chagas disease
Pathology, Diagnosis and Treatment
Clinical phases and forms of Chagas' disease
Diagnosis of Trypanosoma cruzi infection
AIDS and Chagas' disease
Treatment of Chagas disease
Vaccine development for Chagas disease

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