Chemical Genomics and Proteomics

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Chemical Genomics and Proteomics

Format:  Hardcover,

225 pages

Edition: Revised

Publisher: Taylor & Francis

Publish Date: Jan 2013

ISBN-13: 9781439830529

ISBN-10: 1439830525

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Book Information

The following content was provided by the publisher.
This interdisciplinary reference identifies and elucidates the most influential developments in chemical genomics for improved research and advancement in a diverse array of fields ranging from proteomics, bioinformatics, and microfluidics to drug discovery and toxicology. The book tracks the emergence of a large variety of novel techniques such as the small-molecule drugability of new targets, the generation and synthesis of small-molecule libraries, and the determination of targets and mechanisms by genomic profiling and guides readers in the selection of the most appropriate technology for their specific dilemma by highlighting procedures utilized in other scientific disciplines.


Publisher: Taylor & Francis
Publish Date: Jan 2013
ISBN-13: 9781439830529
ISBN-10: 1439830525
Format: Hardcover
Number of Pages: 225
Shipping Weight (in pounds): 1.05
Product in Inches (L x W x H): 6.25 x 9.25 x 0.75

Chapter outline

Utilizing small molecules in chemical genomics: Toward high-throughput (HT) approaches
Development and application of novel analytical methods in lipidomics
From chemical genomics to chemical proteomics: The power of microarray technology
Genomic and proteomic biomarkers in the drug R&D process
Quo vadis biomedical sciences in the omics era: Toward computational biology and medicine
Novel chemogenomic approaches to drug design

Book description

Since the publication of the pioneering first edition of Chemical Genomics and Proteomics more than seven years ago, the area of chemical genomics has rapidly expanded and diversified to numerous novel methods and subdisciplines, such as chemical glycomics and lipidomics. This second edition has been updated to uniquely reflect this interdisciplinary feature as well as the remarkable developments that have occurred. The new edition also covers innovative applications from cell biology to drug discovery to, more recently, clinical diagnostics and medical practice, which utilize the concepts of chemical genomics.

The text provides an overview of the strategies and methodologies of chemical genomics, focusing on emerging technologies and recent applications in the areas of combination chemical genetics, toxicogenomics, drug chemical genomics and proteomics, and orthogonal chemical genetics. It describes the development and application of novel analytical methods used in lipodomics, such as steroidomics. The book also discusses biomarker discovery applications of microarray technologies using DNA, RNA, and protein and glycan arrays. Chapters cover further applications of biomolecular biomarkers for disease diagnosis, in small molecule drug R&D, and during therapeutic use of medicines. These include prognostic, disease specific, response (surrogate), and toxicity biomarkers.

In addition, the text explores the principles of contemporary systems biology and genomics in experimental medicine—a new paradigm that demonstrates a network-oriented view and advanced statistical and informatics data management, opening the way toward personalized medicine. Finally, various in silico chemogenomics approaches are addressed for predicting binding of drug candidates to undesirable targets, which would help in designing better clinical candidates with fewer side effects. This new edition benefits a broad range of readers from industrial and academic researchers in drug discovery, medicinal chemistry, and molecular and cell biology to physicians in clinical diagnostics and students in related fields of study.

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